Serum vitamin D, vitamin D receptor and binding protein genes polymorphisms in restless legs syndrome.

Journal of Neurology
Félix Javier Jiménez-JiménezElena García-Martín

Abstract

Several studies showed lower serum 25-hydroxyvitamin D levels in patients with idiopathic restless legs syndrome (RLS) compared with matched controls, and a single study showed an association between the rs731236 single nucleotide polymorphism (SNP) in the vitamin D receptor (VDR) gene and the risk for RLS. We aimed to study the relationship between the serum 25-hydroxyvitamin D levels and to confirm previous findings related to SNPs in the VDR and the GC vitamin D binding protein (GC) gene, with the risk for RLS in the Spanish Caucasian population. We genotyped 285 idiopathic RLS patients and 325 age and sex-matched controls for VDRrs2228750, VDRrs7975232, VDRrs739837, VDRrs78783628, GCrs7041 and GCrs4588 SNPs using TaqMan assays, and determined serum 25-hydroxyvitamin D levels in 111 idiopathic RLS patients and 167 controls using an ELISA commercial kit. Serum 25-hydroxyvitamin D levels were significantly higher in RLS patients than in controls but were unrelated with the 7 SNPs studied. None of the 7 SNPs analyzed was associated with the risk for idiopathic RLS or with a positive family history of RLS. However, RLS patients carrying the rs7975232CC genotype or the rs7975232C allele, had a higher frequency of response to GABA...Continue Reading

References

Jul 9, 1994·BMJ : British Medical Journal·D G Altman, J M Bland
Nov 1, 2003·Sleep Medicine·Arthur S WaltersUNKNOWN International Restless Legs Syndrome Study Group
Feb 12, 2011·Annals of Human Genetics·Megan W ButlerLiyong Wang
Jun 15, 2011·Molecular and Cellular Endocrinology·James P KesbyJohn J McGrath
Dec 3, 2011·Neurochemistry International·Wayne A CassDavid M Yurek
Jun 19, 2012·Sleep Medicine·Hatice BalabanSuat Topaktaş
Sep 25, 2012·Journal of Neural Transmission·Angela RocoJosé A G Agúndez
Jan 15, 2013·Sleep Medicine·Félix Javier Jiménez-JiménezElena García-Martín
Jun 14, 2013·Fluids and Barriers of the CNS·Stephanie M PattonJames R Connor
Jun 6, 2014·Neuropsychiatric Disease and Treatment·Mustafa OranAhmet Gurel
Oct 11, 2014·Journal of Neural Transmission·Félix Javier Jiménez-JiménezJosé A G Agúndez
Apr 24, 2015·Acta neurologica Belgica·Tuncay ÇakırNaciye Füsun Toraman
Aug 28, 2015·Medicine·Elena García-MartínJosé A G Agúndez
Dec 8, 2015·Neuropsychiatric Disease and Treatment·Kenan CelikMuharrem Kiskac
Nov 12, 2016·Journal of Neural Transmission·Félix Javier Jiménez-JiménezJosé A G Agúndez
Oct 17, 2017·Sleep Medicine Reviews·Félix J Jiménez-JiménezJosé A G Agúndez
Apr 4, 2018·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Siraj WaliMohamed Hamed
May 4, 2018·The Pharmacogenomics Journal·Félix Javier Jiménez-JiménezElena García-Martín
Feb 15, 2019·Neuroscience Letters·Xiong WangKun Tan
Apr 10, 2019·Sleep Medicine Reviews·Félix Javier Jiménez-JiménezJosé A G Agúndez
Jul 5, 2019·CNS & Neurological Disorders Drug Targets·Marzieh SeyediNiyaz Mohammadzadeh Honarvar
Feb 16, 2020·American Journal of Human Genetics·Despoina ManousakiJ Brent Richards

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