Serum Wisteria floribunda agglutinin-positive Mac-2-binding protein levels predict the presence of fibrotic nonalcoholic steatohepatitis (NASH) and NASH cirrhosis

PloS One
Naim AlkhouriAriel E Feldstein

Abstract

The race for finding effective treatments for nonalcoholic fatty liver disease (NAFLD) has been slowed down by the high screen-failure rate for including patients in trials due to the lack of a noninvasive biomarker that can identify patients with significant disease. Recently, Wisteria floribunda agglutinin-positive Mac-2-binding protein (WFA+ -M2BP) has shown promise in predicting liver fibrosis. The aims of this study were to evaluate the utility of WFA+ -M2BP as a biomarker to sub-classify patients with NAFLD according to their disease severity and to assess its correlation with histologic features of NAFLD. Patients undergoing biopsy for clinical suspicion of NAFLD and healthy controls were included. Patients with NAFLD were classified into: NAFL, early NASH (F0-F1), fibrotic NASH (F2-F3), and NASH cirrhosis (F4). Levels of WFA+ -M2BP in sera was measured by a HISCL™ M2BPGi™ assay kit using an automated immunoanalyzer (HISCL™-800; Sysmex, Kobe, Japan). Analysis of covariance was used to assess difference in WFA+ -M2BP between the groups and Spearman's correlation coefficients were used to assess correlation with histological features. Our cohort consisted of 20 healthy controls and 198 patients with biopsy-proven NAFLD div...Continue Reading

References

May 29, 1999·Gastroenterology·C A MatteoniA J McCullough
May 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David E KleinerUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
Sep 9, 2006·Cell·Kazuaki Ohtsubo, Jamey D Marth
Jul 22, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kazumi YamasakiHiroshi Yatsuhashi
Aug 16, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mattias EkstedtRolf Hultcrantz
Apr 14, 2015·Gastroenterology·Eduardo Vilar-GomezManuel Romero-Gomez
Feb 3, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Hiroki NishikawaShuhei Nishiguchi
Mar 24, 2016·Digestive Diseases and Sciences·George Boon-Bee Goh, Arthur J McCullough
Apr 12, 2016·Journal of Hepatology·UNKNOWN European Association for the Study of the Liver (EASL)UNKNOWN European Association for the Study of Obesity (EASO)
Nov 28, 2016·Gastroenterology·Donna L WhiteHashem B El-Serag
Apr 14, 2017·Journal of Gastroenterology and Hepatology·Kiyoaki ItoMasashi Yoneda

❮ Previous
Next ❯

Citations

Aug 25, 2020·Annals of Laboratory Medicine·Nobuharu TamakiNamiki Izumi
Feb 21, 2019·Hepatology International·Leon A Adams
Jun 12, 2020·Seminars in Liver Disease·Leon A Adams, Wah-Kheong Chan
Jan 5, 2021·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Ola G BehairyOla S El-Shimi
Dec 12, 2020·Journal of the Chinese Medical Association : JCMA·Wei-Yu KaoWeu Wang

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

SAS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.