Serum YKL-40 as a potential biomarker of inflammation in psoriasis

The Journal of Dermatological Treatment
A BaranIwona Flisiak

Abstract

YKL-40 is an inflammatory glycoprotein associated with atherosclerosis, cardiovascular disease, diabetes or metabolic syndrome which are common comorbidities in psoriasis. The aim of the study was to assess serum YKL-40 level in psoriasis and elucidate possible associations with disease activity, inflammatory or metabolic parameters and treatment. A total of 37 individuals with active plaque-type psoriasis and 15 healthy controls were enrolled. Blood samples were collected before and after 2 weeks of therapy. Serum YKL-40 concentrations were evaluated by enzyme-linked immunosorbent assay (ELISA). The results were correlated with Psoriasis Area and Severity Index (PASI), body mass index (BMI), inflammatory and biochemical markers, lipid profile and topical therapy. Median YKL-40 serum levels were significantly increased in psoriatic patients in comparison to the controls (p < .0001). No significant correlations between investigated protein and metabolic parameters as BMI (p = .19), glucose (p = .32) nor lipids levels were found. Significant positive relation with CRP (p = .003) or alanine aminotransferase (p = .04) and no correlation with PASI (p = .2) were noted. Serum YKL-40 level remained unchanged (p = .5) after topical trea...Continue Reading

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Citations

Oct 27, 2017·International Journal of Molecular Sciences·Stephen Chu-Sung Hu, Cheng-Che E Lan
Nov 30, 2018·The Journal of Dermatological Treatment·Mohammed Abu El-HamdOla Mahmoud Samy
Aug 29, 2020·Translational Vision Science & Technology·Dhanesh AmarnaniNahyoung Grace Lee
Oct 3, 2020·BMC Cardiovascular Disorders·Yungen JiaoChen Li
Dec 2, 2020·Journal of the American Academy of Dermatology·Youssef A ElnabawiJeffrey S Berger
Oct 2, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yingjian DengXin Su

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