Serum zonulin in patients with inflammatory bowel disease: a pilot study

Minerva medica
Gian Paolo CavigliaMarco Astegiano

Abstract

In recent years it has been supposed that impaired intestinal permeability represents an early event preceding the onset of inflammatory bowel disease (IBD). Since zonulin has been proposed as a biomarker of intestinal permeability, we investigated its role in patients with IBD and the correlation between serum and fecal zonulin. A total of 118 IBD patients (86 Crohn's disease [CD] and 32 ulcerative colitis [UC]) and 23 healthy controls (HC) were prospectively enrolled. A serum sample was collected for all the subjects included in the study. A stool specimen collected in the same day of blood drawing was available for a subgroup of 33 IBD patients. Serum and fecal zonulin were tested by ELISA. Non-parametric statistical tests were used for data analysis. Serum zonulin concentration was higher in IBD patients compared to HC (34.5 [26.5-43.9] ng/mL vs. 8.6 [6.5-12.0] ng/mL, P<0.001) showing an area under the curve of 0.98 for their discrimination. No difference in serum zonulin concentration was observed between patients with CD and those with UC (P=0.074). An inverse correlation was observed between serum zonulin concentration and disease duration (rs=-0.30, P=0.001); no correlation was observed between serum and fecal zonulin (...Continue Reading

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Citations

Feb 9, 2019·American Journal of Physiology. Gastrointestinal and Liver Physiology·Emmeline SalamehRachel Marion-Letellier
Feb 23, 2020·International Journal of Molecular Sciences·Aristo VojdaniDatis Kharrazian
Apr 16, 2020·The Journal of Dermatological Treatment·Mavişe Yüksel, Gözde Ülfer
Mar 4, 2019·Drugs in R&D·Geert R A M D'HaensStefan Schreiber
Apr 25, 2020·World Journal of Gastroenterology : WJG·Vanessa D'AntongiovanniNunzia Bernardini
Jul 28, 2019·Minerva gastroenterologica e dietologica·Marta Vernero
Feb 27, 2020·Journal of the Endocrine Society·Siddhartha S GhoshShobha Ghosh
May 14, 2019·Minerva medica·Davide G Ribaldone, Rinaldo Pellicano
Apr 4, 2021·International Journal of Molecular Sciences·Naschla GasalyMartín Gotteland
Nov 28, 2021·Microorganisms·Francesco Di Pierro
Jan 8, 2022·Critical Reviews in Food Science and Nutrition·Qi SunMei-Jun Zhu

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