Sesame oil attenuates hepatic lipid peroxidation by inhibiting nitric oxide and superoxide anion generation in septic rats

JPEN. Journal of Parenteral and Enteral Nutrition
Dur-Zong HsuMing-Yie Liu

Abstract

Sepsis is a major cause of mortality in the intensive care unit. Oxidative stress plays an important role in the pathogenesis of organ failure during sepsis. Sesame oil decreases circulating oxygen free radicals in septic rats; however, its effect on hepatic oxidative status is unknown. The authors examined the effect of sesame oil on hepatic lipid peroxidation in septic rats. Hepatic injury was induced using cecal ligation and puncture (CLP). Rats were divided into 4 groups: sham, rats given a sham operation without CLP; SO, rats given sesame oil alone; CLP, rats given saline and then CLP; and CS, rats given sesame oil and then CLP. All rats were first given a 1-week daily oral supplement of sesame oil or saline (4 mL/kg/d) and then CLP or a sham operation. The authors assessed hepatic oxidative stress by determining hepatic lipid peroxidation, hydroxyl radical, superoxide anion, and nitric oxide levels 12 hours after CLP. They also assessed xanthine oxidase activity and nitric oxide synthase expression. Hepatic lipid peroxidation (P < .0001), hydroxyl radical (P < .05), superoxide anion (P < .05), and nitrite (P < .05) levels were significantly lower in sesame oil-treated septic rats. Furthermore, sesame oil significantly red...Continue Reading

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Citations

Apr 14, 2012·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Pratibha DubeySukhinder K Cheema
Feb 2, 2010·American Journal of Surgery·Zhen-Ling JiWen-Hao Tang
Sep 6, 2012·The Journal of Clinical Hypertension·Kalliopi KaratziLabros S Sidossis
Jul 8, 2015·Journal of the American College of Nutrition·B HelliM T Jalali
Oct 25, 2016·The Journal of Nutritional Biochemistry·Srinivasan PeriasamyMing-Yie Liu
Jul 24, 2012·JPEN. Journal of Parenteral and Enteral Nutrition·Srinivasan PeriasamyMing-Yie Liu
Dec 18, 2012·JPEN. Journal of Parenteral and Enteral Nutrition·Srinivasan PeriasamyMing-Yie Liu
May 27, 2017·BioImpacts : BI·Fahsai KantawongThasaneeya Kuboki

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Methods Mentioned

BETA
Assay
protein assay
electrophoresis

Software Mentioned

ImageJ
Chemiluminescence Analyzer Data Acquisition

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