PMID: 2095565Dec 1, 1990Paper

Sesquiterpene lactones and other constituents from a cytotoxic extract of Michelia floribunda

Pharmaceutical Research
I O MondranondraN R Farnsworth

Abstract

The pentane and CHCl3 fractions of a crude extract of Michelia floribunda exhibited cytotoxic activity when tested in KB and P388 tumor cell cultures. Repeated chromatography led to the isolation of three cytotoxic sesquiterpene lactones (costunolide, parthenolide, and santamarine) and a cytotoxic isoquinoline alkaloid (liriodenine). Inactive sesquiterpene lactones obtained during the course of this study included dihydroparthenolide and two new glucosides of dihydrotamaulipin A and dihydroreynosin (1 and 2). The structures of these new compounds were determined through interpretation of their spectroscopic data including 2D-NMR spectroscopy. Syringin was also isolated from the extract.

Citations

Aug 14, 2019·Natural Product Research·Tran Thi Hong HanhChau Van Minh
Nov 11, 2008·Cancer Chemotherapy and Pharmacology·Guoyi MaMartin H N Tattersall
Dec 22, 2012·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Dinesh KumarOm Prakash
Dec 11, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ari Satia NugrahaPaul A Keller
Dec 29, 2020·Mitochondrial DNA. Part B, Resources·Yongkang SimaYi Wang

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