Sesquiterpene lactones from Crepis cameroonica (Asteraceae)

Natural Product Research
J C NdomZ T Fomum

Abstract

In addition to one known compound, 3beta,8alpha-dihydroxyguaian-4(15),10(14),11(13)-trien-6,12 olide (8-desacylcynaropicrin) (3), two new sesquiterpene lactones have been isolated from the aerial parts of Crepis cameroonica. By means of spectroscopic analysis, the structures and relative configurations of the new compounds were established as 3beta,9beta-dihydroxyguaian-4(15),10(14),11(13)-trien-6,12 olide (1) and 8alpha-hydroxy-4alpha(13),11beta(15)-tetrahydrozaluzanin C (2). The in vitro antimicrobial spectrum of pure compounds and crude extracts are also reported.

References

Apr 28, 2000·Phytochemistry·D E WedgeF A Macías
Oct 3, 2000·Phytochemistry·W KisieS P Joshi
Feb 20, 2003·Phytochemistry·G N Krishna KumariS Aravind
Dec 1, 1983·Planta medica·W Kisiel

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Citations

Nov 23, 2007·Natural Product Reports·Braulio M Fraga
Mar 6, 2019·Chemistry & Biodiversity·Charlie Kenmoe DjeukeuJean Duplex Wansi
Mar 9, 2019·The Journal of Heredity·Jordan A DowellChase M Mason

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Methods Mentioned

BETA
column chromatography
NMR

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