Sesquiterpene lactones from Inula britannica and their cytotoxic and apoptotic effects on human cancer cell lines

Journal of Natural Products
Naisheng BaiChi-Tang Ho

Abstract

Three new sesquiterpenes (1-3), together with four known sesquiterpene lactones, were isolated from the flowers of Inula britannica var. chinensis. Structures were established on the basis of high-field 1D and 2D NMR methods supported by HRMS. All sesquiterpene lactones were tested for cytotoxicity as well as apoptotic ratio in human COLO 205, HT 29, HL-60, and AGS cancer cells. Compounds 3 and 4, two alpha-methylene gamma-lactone-bearing sesquiterpenes, were modestly active in these assays.

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Citations

Sep 8, 2011·Journal of Natural Products·Jiang-Jiang QinWei-Dong Zhang
Nov 23, 2007·Natural Product Reports·Braulio M Fraga
Jan 7, 2014·Expert Opinion on Investigational Drugs·Guo-Wei WangWei-Dong Zhang
Apr 9, 2013·Food Chemistry·Ming-Hsing HuangLee-Wen Chang
Jan 12, 2010·International Journal of Cardiology·Bin LiuJin-Kun Wen
Feb 27, 2018·Phytotherapy Research : PTR·Maíra Barcellos MariniMichelle Frazão Muzitano
Oct 15, 2013·Angewandte Chemie·Katharina GrafA Stephen K Hashmi
Mar 26, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Abdul Latif KhanIn-Jung Lee
Dec 18, 2010·Immune Network·Jeon Hyeun ChoiEunkyung Lee
May 18, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Angelika KamizelaMagdalena Chmiela
Jun 18, 2015·Chemistry & Biodiversity·Ana M L SecaArtur M S Silva
Jan 8, 2008·Journal of Natural Products·George R PettitJean-Charles Chapuis
May 8, 2021·Journal of Ethnopharmacology·Liu YangHaixue Kuang
Aug 13, 2008·Toxicon : Official Journal of the International Society on Toxinology·Mosaad A Abdel-WahhabAziza A El-Nekeety

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