Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of I kappa B-alpha and I kappa B-beta.

The Journal of Biological Chemistry
S P HehnerM L Schmitz

Abstract

Extracts from certain Mexican Indian medicinal plants used in traditional indigenous medicine for the treatment of inflammations contain sequiterpene lactones (SLs), which specifically inhibit the transcription factor NF-kappa B (Bork, P. M., Schmitz, M. L., Kuhnt, M., Escher, C., and Heinrich, M. (1997) FEBS Lett. 402, 85-90). Here we show that SLs prevented the activation of NF-kappa B by different stimuli such as phorbol esters, tumor necrosis factor-alpha, ligation of the T-cell receptor, and hydrogen peroxide in various cell types. Treatment of cells with SLs prevented the induced degradation of I kappa B-alpha and I kappa B-beta by all these stimuli, suggesting that they interfere with a rather common step in the activation of NF-kappa B. SLs did neither interfere with DNA binding activity of activated NF-kappa B nor with the activity of the protein tyrosine kinases p59fyn and p60arc. Micromolar amounts of SLs prevented the induced expression of the NF-kappa B target gene intracellular adhesion molecule 1. Inhibition of NF-kappa B by SLs resulted in an enhanced cell killing of murine fibroblast cells by tumor necrosis factor-alpha. SLs lacking an exomethylene group in conjugation with the lactone function displayed no inh...Continue Reading

References

May 1, 1992·The Journal of Experimental Medicine·R SchreckP A Baeuerle
Oct 20, 1995·The Journal of Biological Chemistry·S Singh, B B Aggarwal
Jul 1, 1995·Journal of Natural Products·N B Perry, L M Foster
Nov 15, 1995·Genes & Development·I M VermaS Miyamoto
Jan 1, 1994·Annual Review of Immunology·P A Baeuerle, T Henkel
Aug 12, 1994·Science·E Kopp, S Ghosh
Dec 22, 1995·Science·B Frantz, E A O'Neill
Apr 16, 1996·Proceedings of the National Academy of Sciences of the United States of America·J M GriscavageL J Ignarro
Jul 1, 1996·The Journal of Cell Biology·S GrimmK Schulze-Osthoff
Jan 1, 1996·Annual Review of Immunology·A S Baldwin
Apr 1, 1996·The Journal of Antimicrobial Chemotherapy·K HayashiY Takaishi
Jul 1, 1996·Journal of the Neurological Sciences·J G LawrensonG Allt
Oct 4, 1996·Cell·P A Baeuerle, D Baltimore
Nov 1, 1996·Science·D J Van AntwerpI M Verma
Dec 1, 1996·Molecular and Cellular Biology·D J SulcinerT Finkel
Feb 15, 1997·Genes & Development·R PeronaJ C Lacal
Feb 1, 1997·Current Biology : CB·V R Baichwal, P A Baeuerle

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Oct 17, 2009·The Journal of Antibiotics·Takao Kataoka
Oct 12, 1999·British Journal of Pharmacology·B de las HerasA Villar
Aug 14, 1999·European Journal of Biochemistry·S P HehnerM L Schmitz
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