Mar 31, 2009

Sesquiterpene lactones with antinociceptive and antipyretic activity from two Centaurea species

Journal of Ethnopharmacology
Esra Küpeli AkkolErdem Yeşilada


Several Centaurea species are used to alleviate pain and inflammatory symptoms in rheumatoid arthritis, high fever, and head ache in Turkish folk medicine. The effectiveness of extracts, fractions and subfractions from dried Centaurea solstitialis L. subsp. solstitialis (CSS) (Asteraceae) roots and aerial parts were studied on mice. The antinociceptive and antipyretic effects of Centaurea solstitialis L. subsp. solstitialis have been investigated by using p-benzoquinone-induced writhing reflex for antinociceptive activity and Freund's Complete Adjuvant-induced pyrexia model for antipyretic activity assessment in mice. The ethanolic extract from the aerial parts of the plant was shown to possess significant antinociceptive (p < 0.01) and antipyretic activities (p < 0.01). The extract was then submitted to subsequent solvent extractions and chromatographic processes. Through bioassay-guided fractionation and isolation procedures two sesquiterpene lactones, solstitialin A and acetyl solstitialin, were isolated and defined as the active components of CSS. On the other hand, a comparative study was conducted on another species, Centaurea depressa Bieb., which has no similar folkloric utilization. Following the same fractionation cha...Continue Reading

  • References10
  • Citations9


  • References10
  • Citations9


Mentioned in this Paper

Centaurea solstitialis
Antipyretic Effect
Plant Components, Aerial
Plant bulb
Rheumatoid Arthritis
Freund's Adjuvant

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