Sesquiterpenes and other constituents of Xylaria sp. NC1214, a fungal endophyte of the moss Hypnum sp

Phytochemistry
Han WeiA A Leslie Gunatilaka

Abstract

Oxygenated guaiane-type sesquiterpenes, xylaguaianols A-D (1-4), an iso-cadinane-type sesquiterpene isocadinanol A (5), and an α-pyrone 9-hydroxyxylarone (6), together with five known sesquiterpenes (7-11), and four known cytochalasins (12-15) were isolated from a culture broth of Xylaria sp. NC1214, a fungal endophyte of the moss Hypnum sp. The structures of all compounds were elucidated by the analysis of their spectroscopic data and relative configurations of 1-5 were determined with the help of NMR NOESY experiments. Cytochalasins C (12), D (13), and Q (14) were investigated for their cytotoxic activity against five tumor cell lines. Cytochalasin D showed significant cytotoxicity against all five cell lines, with IC50s ranging from 0.22 to 1.44 μM, whereas cytochalasins C and Q exhibited moderate, but selective cytotoxicity.

References

Oct 1, 1992·Phytochemistry·T V SungG Adam
Sep 24, 2004·Phytochemistry·Peter C HealyRohan A Davis
Jul 11, 2006·Magnetic Resonance in Chemistry : MRC·Rohan A Davis, Gregory K Pierens
Sep 28, 2006·Natural Product Reports·Hua Wei ZhangRen Xiang Tan
Jun 5, 2007·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Anja SchüfflerHeidrun Anke
Mar 17, 2009·Magnetic Resonance in Chemistry : MRC·Yan XuZhong-Mei Zou
Nov 9, 2010·Planta medica·Gwendoline Van GoietsenovenAntonio Evidente
Apr 28, 2012·American Journal of Botany·Jana M U'RenA Elizabeth Arnold
Aug 7, 2012·Archives of Pharmacal Research·Saranyoo KlaiklayBoonsom Bussaban
Mar 15, 2014·Journal of Medicinal Chemistry·E M Kithsiri WijeratneA A Leslie Gunatilaka
May 16, 2014·Chemistry & Biodiversity·Fei SongTang Wang
Jul 26, 2014·Archives of Pharmacal Research·Yan-Bo ZengHao-Fu Dai

❮ Previous
Next ❯

Citations

Nov 30, 2016·World Journal of Microbiology & Biotechnology·Martha Lydia Macías-Rubalcava, Rosa Elvira Sánchez-Fernández
Feb 15, 2018·Environmental Microbiology·Jose G Maciá-VicenteHelge B Bode
Dec 22, 2017·Natural Product Research·Carla E BrownJames McNulty
Apr 11, 2018·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Luciana M EliasSimone P Lira
Aug 21, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wei LiYongbiao Zheng
Aug 17, 2019·Natural Product Research·Theerawat PatjanaSirirath McCloskey
Nov 5, 2020·Natural Products and Bioprospecting·Kai-Liang MaKun Gao
Apr 12, 2021·Bioorganic Chemistry·Qing-Feng RuanZhong-Xiang Zhao
May 3, 2019·Journal of Natural Products·Shuai LiuPeter Proksch

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.