Sesquiterpenoids from Carpesium divaricatum and their cytotoxic activity

Fitoterapia
Wei-Dong XieKyung Ho Row

Abstract

In the course of searching for cytotoxic terpenoids from medicinal plants in China, two new eudesmane sesquiterpenoids, 5α-hydroxy-13-methoxy-7αH,11αH-eudesm-4(15)-en-12,8β-lactone (1) and 1β-hydroxy-7αH,11αH-eudesm-4(15)-en-12,8β-lactone (2), along with fourteen known sesquiterpenoids were isolated from the whole plant of Carpesium divaricatum. The structures of new compounds were determined using spectroscopic methods, including IR, HRESIMS, and 1D and 2D NMR spectroscopy. The cytotoxicity of selected sesquiterpene lactones against human oral epidermoid carcinoma (KB), human breast cancer (MCF-7) and human hepatoma (HepG-2) cells was also evaluated by MTT method.

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Citations

Apr 29, 2014·Fitoterapia·Cai-Yan YangJi-Jun Chen
Jul 26, 2013·Natural Product Reports·Braulio M Fraga
Dec 17, 2014·Natural Product Research·Xiujie WangKyungho Row
Feb 3, 2015·Journal of Ethnopharmacology·Jian-Ping ZhangWei-Dong Zhang
Oct 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Zhuo HanXia Li
May 13, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tao ZhangZhong-Mei Zou
Mar 15, 2019·Journal of Natural Products·Nan-Lin ZhuYang Ye

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