Sestamibi versus thallium subtraction scintigraphy in parathyroid localization: a prospective comparative study in patients with predominantly mild primary hyperparathyroidism

Surgery
A BergenfelzS Tibblin

Abstract

Technetium 99m sestamibi was recently introduced for the preoperative localization of abnormal parathyroid glands in patients with primary hyperparathyroidism with promising results. However, the sensitivity of sestamibi and thallium to detect abnormal parathyroid glands is partly dependent on the gland size. In this study we compared the sensitivity of sestamibi subtraction scintigraphy with thallium subtraction scintigraphy in patients with predominantly mild increase in serum calcium level. Thirty-nine patients with primary hyperparathyroidism were included. The mean (+/-SD) serum level of calcium was 2.75 +/- 0.17 mmol/L. In 28 (72%) of the patients the serum level of calcium was less than 2.85 mmol/L. These patients were classified as having mild abnormalities in serum calcium. All patients were investigated before operation with both sestamibi and thallium subtraction scintigraphy. In two patients autonomous thyroid adenomas precluded subtraction scintigraphy. Sestamibi subtraction scintigraphy correctly localized 31 (86%) of 36 parathyroid adenomas compared with only 17 (47%) of 36 by thallium subtraction scintigraphy (p < 0.001). There was one false-positive result in the sestamibi group because of a thyroid adenoma, an...Continue Reading

References

Nov 1, 1991·World Journal of Surgery·S E Carty, J A Norton
Nov 1, 1989·Nuclear Medicine Communications·A J CoakleyR E Collins
Jul 1, 1994·Seminars in Nuclear Medicine·J E Freitas, A E Freitas
Aug 1, 1994·Archives of Surgery·J M RodriquezO H Clark
May 1, 1994·Annals of Surgery·G L IrvinS K Chandarlapaty

❮ Previous
Next ❯

Citations

Jun 24, 2009·Langenbeck's Archives of Surgery·Mark ThierJohan Westerdahl
Jun 8, 2001·Surgical Endoscopy·K K HallfeldtK Horn
Jan 6, 1999·The British Journal of Surgery·F PattouC Proye
Oct 9, 1999·The Australian and New Zealand Journal of Surgery·H TakamiA Kubo
Feb 25, 2000·Current Opinion in Oncology·D L Fraker
Jan 2, 2014·World Journal of Surgery·A BagulS P Balasubramanian
May 21, 1999·Radiographics : a Review Publication of the Radiological Society of North America, Inc·B D Nguyen
Sep 17, 2008·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Hedieh K Eslamy, Harvey A Ziessman
May 17, 2011·Radiologic Clinics of North America·Nathan A JohnsonMitchell E Tublin
May 18, 2004·The Surgical Clinics of North America·Colin Russell
May 13, 2005·Clinical Physiology and Functional Imaging·Christina G ØgardSteen L Nielsen
Jul 21, 2004·Otolaryngologic Clinics of North America·Brian P Mullan
Oct 31, 2000·Radiologic Clinics of North America·N GritzmannT Rettenbacher
Nov 5, 2011·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Emily Z StuckenWilliam I Kuhel
Mar 5, 2005·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·James M RudaBrendan C Stack
Feb 2, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Y S KushchayevaK Kulkarni

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.