SET and MYND domain-containing protein 3 is overexpressed in human glioma and contributes to tumorigenicity

Oncology Reports
Bin DaiLiwei Zhang

Abstract

SET and MYND domain-containing protein 3 (SMYD3) is a histone H3 lysine 4 (H3K4) di- and tri-methyltransferase that forms a transcriptional complex with RNA polymerase II and plays an important role in early embryonic lineage commitment through the activation of lineage-specific genes. SMYD3 activates the transcription of oncogenes and cell cycle genes in gastric and breast cancer cells. However, the contribution of SMYD3 in glioma tumorigenesis remains unknown. Here, we determined the expression of SMYD3 and assessed its clinical significance in human glioma. We found that SMYD3 was overexpressed in human glioma but not in normal brain tissue. The level of SMYD3 protein expression in human glioma tissues was directly correlated with the glioma grade. The level of SMYD3 protein expression in human glioma tissues was inversely correlated with patient survival. Enforced SMYD3 expression promoted glioma LN-18 cell proliferation. Inhibition of SMYD3 expression in glioma T98G cells suppressed their anchorage‑independent growth in vitro and tumorigenicity in vivo. Furthermore, we found that SMYD3 regulated the expression of p53 protein, which is essential in SMYD3‑induced cell growth in glioma cells. These results showed that SMYD3 i...Continue Reading

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Citations

Jul 5, 2019·Journal of Clinical Pathology·Banavathy S KruthikaVani Santosh
Dec 27, 2016·Expert Opinion on Therapeutic Targets·Gurukumari RajajeyabalachandranSriram Rajagopal
Jan 16, 2020·Cancers·Cinzia BottinoGiuseppina Caretti
Feb 28, 2021·Clinical Epigenetics·Benjamin J BernardVassiliki Saloura
May 30, 2021·Nature Communications·Kevin CheesemanJonathan B Weitzman
May 18, 2021·Indian Journal of Surgical Oncology·Pushkar ChandraVijay Kumar Shukla

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