SET Overexpression is Associated with Worse Recurrence-Free Survival in Patients with Primary Breast Cancer Receiving Adjuvant Tamoxifen Treatment

Journal of Clinical Medicine
Yu-Hsiang HuangChun-Yu Liu

Abstract

Adjuvant tamoxifen reduces the recurrence rate of estrogen receptor (ER)-positive breast cancer. Previous in vitro studies have suggested that tamoxifen can affect the cancerous inhibitor of protein phosphatase 2A (CIP2A)/protein phosphatase 2A (PP2A)/phosphorylation Akt (pAkt) signaling in ER-negative breast cancer cells. In addition to CIP2A, SET nuclear proto-oncogene (SET) oncoprotein is another intrinsic inhibitor of PP2A, participating in cancer progression. In the current study, we explored the clinical significance of SET, CIP2A, PP2A, and Akt in patients with ER-positive breast cancer receiving adjuvant tamoxifen. A total of 218 primary breast cancer patients receiving adjuvant tamoxifen with a median follow-up of 106 months were analyzed, of which 17 (7.8%) experienced recurrence or metastasis. In an immunohistochemical (IHC) stain, SET overexpression was independently associated with worse recurrence-free survival (RFS) (hazard ratio = 3.72, 95% confidence interval 1.26⁻10.94, p = 0.017). In silico analysis revealed mRNA expressions of SET, PPP2CA, and AKT1 significantly correlated with worse RFS. In vitro, SET overexpression reduced tamoxifen-induced antitumor effects and drove luciferase activity in an Estrogen rec...Continue Reading

References

Jun 11, 1999·Biochemical and Biophysical Research Communications·S SaitoK Nagata
Oct 31, 2002·The Journal of Biological Chemistry·Núria CanelaOriol Bachs
Sep 8, 2004·Lancet·Bernard FisherUNKNOWN National Surgical Adjuvant Breast and Bowel Project randomised clinical trials
Dec 14, 2004·The New England Journal of Medicine·Soonmyung PaikNorman Wolmark
Nov 2, 2005·Breast Cancer Research and Treatment·Jingbo Liu, Neil Sidell
May 25, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Soonmyung PaikNorman Wolmark
Jul 17, 2007·Cell·Melissa R JunttilaJukka Westermarck
Mar 11, 2008·Trends in Molecular Medicine·Jukka Westermarck, William C Hahn
Dec 2, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mitch DowsettRichard Peto
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Mar 20, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Lee ChengSharon H Giordano
Mar 5, 2013·Cancer Letters·Parthasarathy SeshacharyuluSurinder K Batra
May 4, 2013·The Lancet Oncology·Danilo Perrotti, Paolo Neviani
Jul 31, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Otto Metzger-FilhoFatima Cardoso
Sep 14, 2013·Journal of the National Cancer Institute·Ivana SestakJack Cuzick
Jun 14, 2014·Proceedings of the National Academy of Sciences of the United States of America·Mahnaz JanghorbanRosalie C Sears
Jul 18, 2014·Breast Cancer Research : BCR·Gaia Schiavon, Ian E Smith
Nov 13, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ion CristóbalJesús García-Foncillas
Nov 26, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rachel J D CossettiKaren A Gelmon
Nov 12, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Shi-Wen JiangJiayin Liu

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BETA
KIAA1524

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BETA
transfection

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SPSS

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