Abstract
SET7/9 is a protein lysine methyltransferase that had been initially identified as a histone lysine methyltransferase which generates monomethylation at histone 3 lysine 4. Different functions were attributed to the protein methylation mediated by SET7/9. In this study, we found that the expression of SET7/9 declined in a majority of the human breast cancer tissues examined compared with normal tissues. Knockdown of SET7/9 promoted the proliferation, migration, and invasion of breast cancer cells. Knockdown of SET7/9 also increased the tumorigenicity of breast cancer cells in vivo. On the contrary, overexpression of SET7/9 in breast cancer cells inhibited these processes. Microarray analysis indicated that Gli-1 may play function as a downstream factor of SET7/9. Overexpression of SET7/9SET7/9 inhibits Gli-1 expression. While knockdown of SET7/9 promotes the expression of Gli-1. Gli-1 inhibited by cyclopamine blocked knockdown SET7/9-driven proliferation, migration, and invasion in breast cancer cell. Furthermore, Gli-1 expression in human breast cancer tissues is negatively correlated with SET7/9 expression. Together, these results helped to realize the antioncogene functions of SET7/9 in breast cancer cells and provided a nov...Continue Reading
References
Oct 10, 2002·Cell·Jonathan R WilsonBing Xiao
Jan 7, 2003·The EMBO Journal·Taewoo KwonYunje Cho
Jan 24, 2003·Nature·Bing XiaoSteven J Gamblin
Feb 23, 2005·Archives of Dermatology·Nada C MacaronJack L Arbiser
Jan 18, 2006·Nature Structural & Molecular Biology·Jean-François CoutureRaymond C Trievel
Feb 22, 2007·Plastic and Reconstructive Surgery·Djoned SanantoJuliati H Alsagaff
Feb 19, 2008·Molecular Cell·Julia K KurashFrançois Gaudet
Mar 4, 2008·Journal of the American Chemical Society·Po HuYingkai Zhang
Apr 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Xiaodong Zhang, Thomas C Bruice
Aug 27, 2009·BMC Cancer·Anette ten HaafEdgar Dahl
Feb 9, 2010·Oncogene·S MunroN B La Thangue
Aug 23, 2011·Molecular Cell·Stefano CampanerGiuseppe Testa
Oct 2, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhan-shan WangJi-kun Li
Dec 7, 2013·Cancer Research·Yunshan WangGuangwei Wei
Dec 26, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yunshan WangGuangwei Wei
Jun 4, 2014·CA: a Cancer Journal for Clinicians·Carol E DeSantisAhmedin Jemal
Dec 17, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jianjun LeiXuqi Li
May 23, 2015·The Journal of Biological Chemistry·Kyoko FujimakiHirotaka Watada
Sep 1, 2015·Oncotarget·Larissa LezinaNikolai A Barlev
Sep 4, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ming LiuJing Li
Oct 6, 2015·Scientific Reports·Shuying HeLih-Ling Lin
Citations
Mar 3, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hong DingKai Xian Chen
Aug 31, 2018·International Journal of Molecular Sciences·Maja SabolSonja Levanat
Feb 14, 2019·Cells·Paweł NiewiadomskiKatarzyna Chojnowska
Mar 28, 2020·European Journal of Nutrition·Melina MitsiogianniMihalis I Panayiotidis
Jul 18, 2018·Signal Transduction and Targeted Therapy·Inês de Albuquerque Almeida Batista, Luisa Alejandra Helguero
Nov 7, 2019·Biomarker Research·Mingzhou GuoJames G Herman
Jan 27, 2021·International Journal of Molecular Sciences·Sidney IrianaNeelam Sharma-Walia
Nov 22, 2019·Biochimica Et Biophysica Acta. Molecular Cell Research·Arun MaheshArunkumar Dhayalan
Feb 20, 2021·Clinical Epigenetics·Cecilia Fernández-PonceElkin Navarro Quiroz
May 9, 2021·Investigational New Drugs·Melina MitsiogianniMihalis I Panayiotidis
Jun 24, 2021·Epigenetics : Official Journal of the DNA Methylation Society·Rieke SchröderJesús Duque-Afonso
Oct 26, 2021·Frontiers in Oncology·Alexandra DaksNickolai A Barlev