Setaria digitata secreted filarial lipids modulate IL-12 signaling through JAK-STAT pathway leading to the development of Th1 response

Experimental Parasitology
Gladson MuthianJ J Bright

Abstract

Filariasis is a debilitating parasitic disease in many tropical countries. Despite the highly evolved immune system, the filarial parasites successfully evade host immunity to persist for a sustained period of time. Earlier studies have shown that the filarial parasites achieve this long-term survival through release of immunosuppressive materials in the host. In this study, we show that the secreted filarial lipids (SFL) isolated from Setaria digitata suppress Th1 immune response. While immunization with myelin antigen induces Th1 response in mice, in vitro treatment with SFL resulted in a dose-dependent decrease in myelin antigen-induced proliferation and secretion of IL-12 and IFNgamma. The SFL also inhibited IL-12-induced T cell proliferation and Th1 differentiation in vitro. The inhibition of T cell responses by SFL associates with the blockade of IL-12-induced activation of JAK-STAT signaling pathway in T cells. These findings suggest that the SFL modulates Th1 immune response by blocking IL-12 signaling in T cells and thus play a role in host immune evasion of filarial parasites.

References

Jan 1, 1990·Molecular and Biochemical Parasitology·J G MercerH H Rees
Oct 1, 1995·Molecular and Cellular Biology·T L MurphyK M Murphy
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·C M BaconJ J O'Shea
Nov 30, 1994·Biochemical and Biophysical Research Communications·G A KumariR K Raj
Jul 4, 1998·Parasite Immunology·J E Allen, A S MacDonald
Jan 5, 2000·Microbes and Infection·A B de Almeida, D O Freedman
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·C L KingJ W Kazura
Jun 19, 2001·International Journal for Parasitology·R M MaizelsX Zang
Aug 14, 2001·Infection and Immunity·R T SemnaniT B Nutman
Aug 28, 2001·Veterinary Parasitology·R A Lawrence
Jun 11, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chandramohan Natarajan, John J Bright
Feb 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Edward MitreThomas B Nutman
Jul 6, 2004·Immunology Letters·William HarnettMargaret M Harnett
Sep 14, 2004·Immunological Reviews·Rick M MaizelsJudith E Allen

❮ Previous
Next ❯

Citations

Nov 24, 2011·International Journal of Biological Sciences·Mireya Becerra-DíazLuis I Terrazas
Jun 1, 2014·Archivum Immunologiae Et Therapiae Experimentalis·Mahmoud Abdel-LatifAl-Mahy El-Mallah
May 1, 2015·Journal of Helminthology·A N I PerumalR S Dassanayake
Jun 28, 2019·Current Topics in Medicinal Chemistry·Anuradha KalaniPankaj Chaturvedi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody-Dependent Cell Cytotoxicity

Antibody-dependent cellular toxicity refers to the lysis of a target cell by a non-sensitized effector cell of the immune system as a result of antibodies binding to the target cell membrane and engaging the Fc receptors on the immune effector cells. Find the latest research on antibody-dependent cellular toxicity here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Antigenic Modulation

Antigenic modulation occurs when an antibody cross-links antigens on a cell surface, causing the antigens to become internalized. This can lead to therapeutic failure of monoclonal antibodies as the expression of the antigen becomes decreased on target cells. Find the latest research on antigenic modulation here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.