Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins.

Neuron
Qing-Jun MengAndrew S I Loudon

Abstract

The intrinsic period of circadian clocks is their defining adaptive property. To identify the biochemical mechanisms whereby casein kinase1 (CK1) determines circadian period in mammals, we created mouse null and tau mutants of Ck1 epsilon. Circadian period lengthened in CK1epsilon-/-, whereas CK1epsilon(tau/tau) shortened circadian period of behavior in vivo and suprachiasmatic nucleus firing rates in vitro, by accelerating PERIOD-dependent molecular feedback loops. CK1epsilon(tau/tau) also accelerated molecular oscillations in peripheral tissues, revealing its global role in circadian pacemaking. CK1epsilon(tau) acted by promoting degradation of both nuclear and cytoplasmic PERIOD, but not CRYPTOCHROME, proteins. Together, these whole-animal and biochemical studies explain how tau, as a gain-of-function mutation, acts at a specific circadian phase to promote degradation of PERIOD proteins and thereby accelerate the mammalian clockwork in brain and periphery.

References

Sep 2, 1988·Science·M R Ralph, M Menaker
Apr 1, 1996·Molecular and Cellular Biology·A Abuin, A Bradley
Oct 10, 2001·The Journal of Biological Chemistry·E L VielhaberD M Virshup
Aug 29, 2002·Nature·Steven M Reppert, David R Weaver
Aug 2, 2003·Nature Reviews. Neuroscience·Michael H HastingsElizabeth S Maywood
Dec 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Mariko IzumoShin Yamazaki
Feb 14, 2004·Proceedings of the National Academy of Sciences of the United States of America·Seung-Hee YooJoseph S Takahashi
Oct 16, 2004·Annual Review of Genomics and Human Genetics·Phillip L Lowrey, Joseph S Takahashi
Oct 28, 2005·Nature·Clifford B SaperJun Lu
Dec 2, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Timothy M BrownHugh D Piggins
Jul 5, 2006·Proceedings of the National Academy of Sciences of the United States of America·Monica GallegoDaniel B Forger
Jan 5, 2007·Proceedings of the National Academy of Sciences of the United States of America·Haydn M ProsserElizabeth S Maywood
Jan 16, 2007·Cell·Emmanuel Mignot, Joseph S Takahashi
Jan 25, 2007·Nature Reviews. Molecular Cell Biology·Monica Gallego, David M Virshup

❮ Previous
Next ❯

Citations

Nov 20, 2012·Cellular and Molecular Life Sciences : CMLS·Zheng ChenJoseph S Takahashi
Dec 4, 2008·Psychopharmacology·Camron D BryantAbraham A Palmer
Oct 23, 2012·Cell Reports·Craig C JolleyHiroki R Ueda
Jul 28, 2013·Experimental & Molecular Medicine·Yongjin Lee, Eun-Kyoung Kim
Dec 7, 2010·Nature Neuroscience·Christopher M CiarleglioDouglas G McMahon
Nov 18, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Camron D BryantAbraham A Palmer
May 3, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Stéphanie Perreau-LenzRainer Spanagel
Nov 26, 2009·Nature Reviews. Cancer·Saurabh Sahar, Paolo Sassone-Corsi
Sep 20, 2008·Nature Reviews. Genetics·Joseph S TakahashiErin L McDearmon
Feb 11, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jennifer A MohawkMichael Menaker
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Alexis B WebbErik D Herzog
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Yasushi IsojimaHiroki R Ueda
Aug 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Qing-Jun MengAndrew S I Loudon
Jul 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·Elizabeth S MaywoodMichael H Hastings
Sep 21, 2011·Proceedings of the National Academy of Sciences of the United States of America·Hyeong-min LeeChoogon Lee
Oct 5, 2011·Proceedings of the National Academy of Sciences of the United States of America·William J SchwartzHoracio O de la Iglesia
May 25, 2012·Proceedings of the National Academy of Sciences of the United States of America·Masafumi ToyoshimaCarla Grandori
Apr 12, 2012·Human Molecular Genetics·Melanie LacariaJames R Lupski
Mar 1, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sibah HasanDerk-Jan Dijk
Jul 3, 2008·Genes & Development·Justin Blau
Nov 8, 2008·Science·Joseph S TakahashiVivek Kumar
May 6, 2009·Molecular and Cellular Biology·Jean-Pierre EtchegarayDavid R Weaver
Jan 9, 2010·Annual Review of Pharmacology and Toxicology·Georgios K PaschosGarret A FitzGerald
Sep 17, 2009·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Anja C UtzUwe Knippschild
Mar 13, 2009·PLoS Biology·Julie E BaggsJohn B Hogenesch
Oct 23, 2010·PLoS Biology·Caroline H KoJoseph S Takahashi
Nov 20, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Julie S PendergastShin Yamazaki
Jan 16, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bikem AktenF Rob Jackson
Jul 20, 2012·Molecular Medicine·Christos Savvidis, Michael Koutsilieris

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.