Setting exposure standards: a decision process

Environmental Health Perspectives
H A TilsonK M Crofton

Abstract

Increased emphasis on routine screening of chemicals for potential neurotoxicity has resulted in the development of testing guidelines and standardized procedures. A multiphased, tiered-testing strategy has been proposed by numerous expert panels to evaluate large numbers of chemicals. In a regulatory context, however, a formal tiered-testing approach is not used, mostly because of the constraints of differing regulatory authorities and the potential cost of such a testing strategy. Instead, current regulatory decision making utilizes all available animal and human data to identify a critical adverse effect which is then used for setting standards. Although the current decision-making process does not use a formal tiered-testing approach, it appears to identify chemicals with neurotoxic effects. An analysis of U.S. Environmental Protection Agency integrated risk information system (IRIS) indicates that about 20% of the chemicals having standards or health advisories are based on neurotoxicity.

References

Jul 1, 1990·Neurotoxicology and Teratology·H A Tilson
Jan 1, 1988·Critical Reviews in Toxicology·C A Kimmel
Dec 1, 1988·Regulatory Toxicology and Pharmacology : RTP·D G Barnes, M Dourson

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Citations

Jun 15, 2000·Environmental Health Perspectives·H A Tilson
Apr 1, 1996·Environmental Health Perspectives·B KuligD Peakall
Apr 1, 1996·Environmental Health Perspectives·D HattisB Ulbrich
May 17, 2005·International Archives of Occupational and Environmental Health·Roberto LucchiniLorenzo Alessio
Jun 9, 2005·Neurotoxicology and Teratology·William SlikkerThomas J Sobotka

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