Setting priorities for a research agenda to combat drug-resistant tuberculosis in children

Public Health Action
B VelayuthamS Swaminathan

Abstract

Numerous knowledge gaps hamper the prevention and treatment of childhood drug-resistant tuberculosis (TB). Identifying research priorities is vital to inform and develop strategies to address this neglected problem. To systematically identify and rank research priorities in childhood drug-resistant TB. Adapting the Child Health and Nutrition Research Initiative (CHNRI) methodology, we compiled 53 research questions in four research areas, then classified the questions into three research types. We invited experts in childhood drug-resistant TB to score these questions through an online survey. A total of 81 respondents participated in the survey. The top-ranked research question was to identify the best combination of existing diagnostic tools for early diagnosis. Highly ranked treatment-related questions centred on the reasons for and interventions to improve treatment outcomes, adverse effects of drugs and optimal treatment duration. The prevalence of drug-resistant TB was the highest-ranked question in the epidemiology area. The development type questions that ranked highest focused on interventions for optimal diagnosis, treatment and modalities for treatment delivery. This is the first effort to identify and rank research ...Continue Reading

Citations

Oct 31, 2016·Environmental Toxicology and Pharmacology·Arpitha RaoSatish Kumar Adiga
Oct 17, 2018·Assay and Drug Development Technologies·Priscila Cristina Bartolomeu HalickiDaniela Fernandes Ramos
Nov 16, 2019·American Journal of Respiratory and Critical Care Medicine·Payam NahidBarbara Seaworth
Sep 24, 2020·Expert Review of Respiratory Medicine·James A SeddonH Simon Schaaf

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