Setting priorities for comparative effectiveness research in inflammatory bowel disease: results of an international provider survey, expert RAND panel, and patient focus groups

Inflammatory Bowel Diseases
Adam S CheifetzCorey A Siegel

Abstract

Comparative effectiveness research (CER) is an emerging field that compares the relative effectiveness of alternative strategies to prevent, diagnose, or treat patients who are typical of day-to-day practice. We developed a priority list of CER topics for inflammatory bowel disease (IBD). Following the Institute of Medicine's approach, we developed and administered a survey to gastroenterologists asking for important CER topics in IBD. Two patient focus groups were convened to solicit additional CER studies. CER topics were presented to the expert panel using the RAND/UCLA methodology. Following initial ratings, the panel met to discuss and re-rate priorities. The top 10 CER topics were identified using a point-allocation system. Responses were collated into 234 CER topics across 21 categories, of which 87 were prioritized for discussion and re-rated. Disagreement regarding priorities was observed in 5 of 87 studies. We utilized a point-allocation system to prioritize the top-10 CER topics. These related to comparing the effectiveness of: biomarkers in IBD; withdrawal of anti-tumor necrosis factor (TNF) or immunomodulators for Crohn's disease in remission; mucosal healing as an endpoint of treatment; infliximab levels versus st...Continue Reading

References

Apr 20, 2007·Medical Care·Darren A DeWaltUNKNOWN PROMIS Cooperative Group
Jul 2, 2009·Annals of Internal Medicine·Harold C Sox, Sheldon Greenfield
Apr 16, 2010·The New England Journal of Medicine·Jean Frédéric ColombelUNKNOWN SONIC Study Group
Mar 23, 2011·Inflammatory Bowel Diseases·Eoin Slattery, Gavin C Harewood

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Citations

Aug 12, 2014·Gastroenterology Clinics of North America·Mark A SamaanBarrett G Levesque
Aug 7, 2014·Expert Review of Gastroenterology & Hepatology·Mark H Flasar, Raymond K Cross
May 18, 2016·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Gil Y MelmedCorey A Siegel
Aug 12, 2017·Journal of Human Nutrition and Dietetics : the Official Journal of the British Dietetic Association·M C LomerJ Mclaughlin
Mar 14, 2012·Nature Reviews. Gastroenterology & Hepatology·Isobel Franks
Apr 6, 2021·Journal of Gastroenterology and Hepatology·Parambir S Dulai

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