Setting sights on the treatment of ocular angiogenesis using antisense oligonucleotides

Trends in Pharmacological Sciences
Scott P HenryNicholas M Dean

Abstract

The application of antisense technology to study physiological and disease processes continues to mature. Antisense approaches are among the most direct means to use genomic sequence information. When developing therapeutics, applications range from early target validation in discovery to the therapeutic product. In this review, we describe the application of antisense oligonucleotides (ASOs) to identify genes that are important in controlling angiogenesis. High-throughput assays in vitro have been used to evaluate many gene targets. Genes that appear to be important in angiogenesis are then evaluated further in animal models of ocular angiogenesis. The ability of ASOs to reduce target-gene expression in the appropriate cells in the eye raises the possibility that this class of compounds could be used for target validation in vivo, and also be developed as a novel class of therapeutics in their own right.

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Citations

Sep 10, 2010·Progress in Retinal and Eye Research·Yolanda Diebold, Margarita Calonge
Feb 25, 2009·Child Development·Laurence SteinbergMarie Banich
Nov 26, 2005·Angiogenesis·John K JacksonHelen M Burt

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