Setting Standards for Reporting and Quantification in Fluorescence-Guided Surgery

Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging
Charlotte HoogstinsJacobus Burggraaf

Abstract

Intraoperative fluorescence imaging (FI) is a promising technique that could potentially guide oncologic surgeons toward more radical resections and thus improve clinical outcome. Despite the increase in the number of clinical trials, fluorescent agents and imaging systems for intraoperative FI, a standardized approach for imaging system performance assessment and post-acquisition image analysis is currently unavailable. We conducted a systematic, controlled comparison between two commercially available imaging systems using a novel calibration device for FI systems and various fluorescent agents. In addition, we analyzed fluorescence images from previous studies to evaluate signal-to-background ratio (SBR) and determinants of SBR. Using the calibration device, imaging system performance could be quantified and compared, exposing relevant differences in sensitivity. Image analysis demonstrated a profound influence of background noise and the selection of the background on SBR. In this article, we suggest clear approaches for the quantification of imaging system performance assessment and post-acquisition image analysis, attempting to set new standards in the field of FI.

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Citations

Oct 7, 2018·Journal of Biomedical Optics·Brian W PogueGooitzen M van Dam
Jul 2, 2019·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Jacqueline van den BosLaurents P S Stassen
Dec 11, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Nicholas E WojtynekAaron M Mohs
Jun 28, 2019·Frontiers in Surgery·Pablo A ValdesAlexandra J Golby
Mar 26, 2021·The Lancet Oncology·Lorraine J LauwerendsStijn Keereweer
Jun 9, 2021·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Feredun AzariSunil Singhal
May 19, 2021·Journal of Biomedical Optics·Feredun AzariSunil Singhal
Sep 9, 2021·Nature Reviews. Clinical Oncology·J Sven D MieogAlexander L Vahrmeijer

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