Setting the main circadian clock of a diurnal mammal by hypocaloric feeding.

The Journal of Physiology
J MendozaE Challet

Abstract

Caloric restriction attenuates the onset of a number of pathologies related to ageing. In mammals, circadian rhythms, controlled by the hypothalamic suprachiasmatic (SCN) clock, are altered with ageing. Although light is the main synchronizer for the clock, a daily hypocaloric feeding (HF) may also modulate the SCN activity in nocturnal rodents. Here we report that a HF also affects behavioural, physiological and molecular circadian rhythms of the diurnal rodent Arvicanthis ansorgei. Under constant darkness HF, but not normocaloric feeding (NF), entrains circadian behaviour. Under a light–dark cycle, HF at midnight led to phase delays of the rhythms of locomotor activity and plasma corticosterone. Furthermore, Per2 and vasopressin gene oscillations in the SCN were phase delayed in HF Arvicanthis compared with animals fed ad libitum. Moreover, light-induced expression of Per genes in the SCN was modified in HF Arvicanthis, despite a non-significant effect on light-induced behavioural phase delays. Together, our data show that HF affects the circadian system of the diurnal rodent Arvicanthis ansorgei differentially from nocturnal rodents. The Arvicanthis model has relevance for the potential use of HF to manipulate circadian rhyt...Continue Reading

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Citations

Mar 29, 2014·Nutrition Research Reviews·Jonathan D Johnston
Jan 10, 2013·Trends in Endocrinology and Metabolism : TEM·Maria Florencia TevyManlio Vinciguerra
Apr 3, 2019·International Journal of Molecular Sciences·Eleonore Maury
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Dec 1, 2020·Temperature : Multidisciplinary Biomedical Journal·Roberto Refinetti
Apr 3, 2019·Trends in Endocrinology and Metabolism : TEM·Jorge Mendoza

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