Setting the Threshold for Surgical Prevention in Women at Increased Risk of Ovarian Cancer

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Ranjit Manchanda, Usha Menon

Abstract

The number of ovarian cancer cases is predicted to rise by 14% in Europe and 55% worldwide over the next 2 decades. The current absence of a screening program, rising drug/treatment costs, and only marginal improvements in survival seen over the past 30 years suggest the need for maximizing primary surgical prevention to reduce the burden of ovarian cancer. Primary surgical prevention through risk-reducing salpingo-oophorectomy (RRSO) is well established as the most effective method for preventing ovarian cancer. In the UK, it has traditionally been offered to high-risk women (>10% lifetime risk of ovarian cancer) who have completed their family. The cost-effectiveness of RRSO in BRCA1/BRCA2 carriers older than 35 years is well established. Recently, RRSO has been shown to be cost-effective in postmenopausal women at lifetime ovarian cancer risks of 5% or greater and in premenopausal women at lifetime risks greater than 4%. The acceptability, uptake, and satisfaction with RRSO at these intermediate-risk levels remain to be established. Prospective outcome data on risk-reducing salpingectomy and delayed-oophorectomy for preventing ovarian cancer is lacking, and hence, this is best offered for primary prevention within the contex...Continue Reading

References

Apr 10, 1995·American Journal of Medical Genetics·M J SellerG S Tint
Feb 7, 2002·Journal of the National Cancer Institute·M Elske van den Akker-van MarleJ Dik F Habbema
Sep 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joanna B MadalinskaNeil K Aaronson
Oct 13, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Timothy R RebbeckUNKNOWN PROSE Study Group
Mar 22, 2006·Annals of Internal Medicine·Kristin AndersonVictor R Grann
Apr 10, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sining Chen, Giovanni Parmigiani
Jul 8, 2008·Gastroenterology·Leigha SenterAlbert de la Chapelle
Jan 15, 2009·Journal of the National Cancer Institute·Timothy R RebbeckSusan M Domchek
Sep 3, 2010·JAMA : the Journal of the American Medical Association·Susan M DomchekTimothy R Rebbeck
Dec 15, 2010·The Lancet Oncology·Marlies J E KempersMarjolijn J L Ligtenberg
Mar 12, 2011·BJOG : an International Journal of Obstetrics and Gynaecology·R ManchandaU Menon
Aug 9, 2011·Nature Genetics·Chey LovedayNazneen Rahman
Feb 22, 2012·Menopause : the Journal of the North American Menopause Society·Siobán D HarlowUNKNOWN STRAW 10 Collaborative Group
Apr 28, 2012·Nature Genetics·Chey LovedayNazneen Rahman
Dec 6, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Adam N RosenthalIan J Jacobs
Apr 23, 2013·Familial Cancer·Emma BarrowD Gareth Evans
May 1, 2013·Journal of the National Cancer Institute·Nasim MavaddatUNKNOWN EMBRACE
Dec 17, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sanne W ten BroekeJuul T Wijnen
Jan 13, 2015·Nature Genetics·Karoline B KuchenbaeckerUNKNOWN Consortium of Investigators of Modifiers of BRCA1 and BRCA2
Jan 28, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Celeste Leigh PearcePaul D P Pharoah
Oct 5, 2016·American Journal of Epidemiology·Merlise A ClydeUNKNOWN , on behalf of the Ovarian Cancer Association Consortium
Jan 21, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Emily E K MeserveChristopher P Crum
Feb 13, 2017·BJOG : an International Journal of Obstetrics and Gynaecology·A DareliusA Strandell
Feb 28, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Adam N RosenthalUNKNOWN United Kingdom Familial Ovarian Cancer Screening Study collaborators
Jun 15, 2017·American Journal of Obstetrics and Gynecology·Carmen GanRanjit Manchanda
Jun 21, 2017·JAMA : the Journal of the American Medical Association·Karoline B KuchenbaeckerHåkan Olsson

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