Sevelamer hydrochloride (Renagel), a nonabsorbed phosphate-binding polymer, does not interfere with digoxin or warfarin pharmacokinetics

Journal of Clinical Pharmacology
S K BurkeN Watson


Sevelamer hydrochloride (Renagel) is a nonabsorbed phosphate-binding polymer marketed for the treatment of hyperphosphatemia in adult patients receiving hemodialysis. Sevelamer also exhibits bile acid-binding properties resulting in LDL cholesterol lowering. Potential drug interactions between digoxin and warfarin and sevelamer were studied. These two drugs were chosen because they are known to bind to the bile acid-binding polymers, cholestyramine and colestipol. Studies were single dose, crossover, with or without six 2.4 g doses of sevelamer. Plasma concentrations were determined using validated analytical methods. The pharmacokinetic profiles of digoxin and warfarin were not altered by the simultaneous and continued administration of sevelamer. Values for the ratio of ln[AUC(0-infinity)], ln[AUC(0-t)], and ln[Cmax] with and without sevelamer were close to 100%, and the 90% confidence intervals for these ratios were within the 80% to 125% range. It was concluded that sevelamer does not interfere with the absorption or excretion of digoxin or warfarin.


May 1, 1978·British Journal of Clinical Pharmacology·E JähnchenU Groth
Jan 1, 1990·Journal of Clinical Pharmacology·S C ForlandR E Cutler
Aug 1, 1989·Journal of Clinical Pharmacology·H FriedmanB W LeDuc
Mar 1, 1988·Archives of Internal Medicine·R P Henderson, C P Solomon
Feb 1, 1988·British Journal of Clinical Pharmacology·P J NeuvonenE L Hirvisalo
May 1, 1971·Clinical Pharmacology and Therapeutics·D S RobinsonJ J McCormack
Sep 1, 1984·British Journal of Clinical Pharmacology·D M HibbardD B Hunninghake
Apr 9, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A J BleyerE Slatopolsky
Nov 26, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·G M ChertowE Slatopolsky


Jul 28, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hanneke W H A FleurenErnst J Vollaard
Nov 14, 2001·Current Opinion in Nephrology and Hypertension·K UhligA K Singh
Dec 20, 2012·Therapeutic Advances in Chronic Disease·Mario CozzolinoMaurizio Gallieni
Dec 5, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Michael B KaysKevin M Sowinski
Jun 5, 2003·Expert Opinion on Pharmacotherapy·A J Bleyer
Jan 5, 2002·Pharmacoepidemiology and Drug Safety
Sep 7, 2011·Nature Reviews. Nephrology·Alastair J HutchisonPaul E C Brenchley
Oct 28, 2010·Expert Opinion on Pharmacotherapy·Patrick Biggar, Markus Ketteler
Nov 19, 2020·The Journal of Pharmacology and Experimental Therapeutics·Tamara R CastañedaThomas Hübschle

Related Concepts

Sevelamer carbonate
Indirect Thrombin Inhibitors
Cardiotonic Agents
Drug Interactions
Epoxy Compounds

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.