Sevelamer hydrochloride (Renagel), a nonabsorbed phosphate-binding polymer, does not interfere with digoxin or warfarin pharmacokinetics

Journal of Clinical Pharmacology
S K BurkeN Watson

Abstract

Sevelamer hydrochloride (Renagel) is a nonabsorbed phosphate-binding polymer marketed for the treatment of hyperphosphatemia in adult patients receiving hemodialysis. Sevelamer also exhibits bile acid-binding properties resulting in LDL cholesterol lowering. Potential drug interactions between digoxin and warfarin and sevelamer were studied. These two drugs were chosen because they are known to bind to the bile acid-binding polymers, cholestyramine and colestipol. Studies were single dose, crossover, with or without six 2.4 g doses of sevelamer. Plasma concentrations were determined using validated analytical methods. The pharmacokinetic profiles of digoxin and warfarin were not altered by the simultaneous and continued administration of sevelamer. Values for the ratio of ln[AUC(0-infinity)], ln[AUC(0-t)], and ln[Cmax] with and without sevelamer were close to 100%, and the 90% confidence intervals for these ratios were within the 80% to 125% range. It was concluded that sevelamer does not interfere with the absorption or excretion of digoxin or warfarin.

References

May 1, 1978·British Journal of Clinical Pharmacology·E JähnchenU Groth
Jan 1, 1990·Journal of Clinical Pharmacology·S C ForlandR E Cutler
Aug 1, 1989·Journal of Clinical Pharmacology·H FriedmanB W LeDuc
Mar 1, 1988·Archives of Internal Medicine·R P Henderson, C P Solomon
Feb 1, 1988·British Journal of Clinical Pharmacology·P J NeuvonenE L Hirvisalo
May 1, 1971·Clinical Pharmacology and Therapeutics·D S RobinsonJ J McCormack
Sep 1, 1984·British Journal of Clinical Pharmacology·D M HibbardD B Hunninghake
Apr 9, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A J BleyerE Slatopolsky
Nov 26, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·G M ChertowE Slatopolsky

Citations

Jul 28, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hanneke W H A FleurenErnst J Vollaard
Nov 14, 2001·Current Opinion in Nephrology and Hypertension·K UhligA K Singh
Dec 20, 2012·Therapeutic Advances in Chronic Disease·Mario CozzolinoMaurizio Gallieni
Dec 5, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Michael B KaysKevin M Sowinski
Jun 5, 2003·Expert Opinion on Pharmacotherapy·A J Bleyer
Jan 5, 2002·Pharmacoepidemiology and Drug Safety
Sep 7, 2011·Nature Reviews. Nephrology·Alastair J HutchisonPaul E C Brenchley
Oct 28, 2010·Expert Opinion on Pharmacotherapy·Patrick Biggar, Markus Ketteler
Nov 19, 2020·The Journal of Pharmacology and Experimental Therapeutics·Tamara R CastañedaThomas Hübschle

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