Seven criteria for improving effectiveness trials in psychiatry

Psychological Medicine
Michele TansellaBenedetto Saraceno

Abstract

There are no published criteria for improving the quality of effectiveness of randomized controlled trials (RCTs) in psychiatry. The authors review and systematize the relevant literature on effectiveness trials, with particular reference to psychiatry. In planning effectiveness RCTs in psychiatry, seven sets of issues need to be carefully considered: (i) study question (i.e. is the study question expressed in an answerable way?); (ii) reference population (i.e. what is the reference group or subgroup to which the trial results should be generalized?); (iii) patient sample (i.e. how far does the sample reflect the target population?); (iv) study settings (i.e. how representative are the study settings of routine clinical sites?); (v) study interventions (i.e. is the study intervention manualized, acceptable to patients and suitable for widespread use?); (vi) control condition (i.e. are the key characteristics of the control condition well described, and do they vary within and between sites?); and (vii) bias (e.g. attrition, blinding, concealment, consent and contamination). More effectiveness trials are needed which have sufficient statistical power to provide precise answers to assist clinicians in making treatment decisions....Continue Reading

Citations

Feb 16, 2011·Psychological Medicine·G ThornicroftM Tansella
Nov 13, 2008·BMJ : British Medical Journal·Merrick ZwarensteinUNKNOWN Pragmatic Trials in Healthcare (Practihc) group
Sep 11, 2009·Journal of Clinical Epidemiology·Laura L ZettlerRobert W Teasell
Jul 1, 2008·General Hospital Psychiatry·Biancamaria BortolottiDomenico Berardi
Oct 21, 2010·Journal of Clinical Nursing·Michelle ClearyDebra Jackson
Mar 23, 2011·Perspectives in Psychiatric Care·Jan HorsfallGlenn E Hunt
May 12, 2012·The British Journal of Clinical Psychology·Janet D FeigenbaumPaul E Bebbington
Feb 8, 2014·Issues in Mental Health Nursing·Abdulkarim Subhi Alzayyat
Jul 30, 2014·Psychological Medicine·M PurgatoC Adams
Dec 18, 2012·Thérapie·Sophie StamenkovicUNKNOWN le groupe Intérêt de santé publique et études post-inscription (ISPEP)
Feb 3, 2007·The British Journal of Psychiatry : the Journal of Mental Science·Corrado Barbui, Silvio Garattini
Oct 18, 2008·Epidemiologia e psichiatria sociale·Antonio VeroneseCorrado Barbui
Oct 18, 2019·The Cochrane Database of Systematic Reviews·Janina JochimAndrea Cipriani

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