Abstract
The purpose of the study is to clarify the effect of 7 days of ethanol administration upon brain histaminergic neurons in rats. Male Wistar rats were injected intraperitoneally (i.p.) with 20% ethanol/saline (0.85% NaCl) daily, over 7 days, whereas control rats were given saline. The animals were decapitated 24 h after the 7th injection and samples of hypothalamus were prepared for light and electron microscopy, accompanied by morphometry to examine the histaminergic neurons. It was found that ethanol administration gradually decreased the duration of alcohol-induced sleep and decreased the total amount of histaminergic neurons and the amount of histologically normal neurons, but increased the amount of hypochromic neurons and shadow cells. The histaminergic neuron bodies and nuclei decreased in size. The ultrastructural changes in histaminergic neurons demonstrated activation of their nuclear apparatus, both destruction or hypertrophy and hyperplasia of organelles, especially lysosomes. The histochemical examination revealed the activation of lactate dehydrogenase and acid phosphatase, and inhibition of NADH-, NADPhH, and succinate dehydrogenases. Following 7 days of ethanol administration, histaminergic neurons exhibit the st...Continue Reading
References
May 1, 1991·Agents and Actions·W A FogelC Maslinski
Dec 1, 1987·Alcoholism, Clinical and Experimental Research·W Ambroziak, R Pietruszko
Dec 1, 1985·Journal of Neurochemistry·Y ItohK Saeki
Jan 1, 1982·Progress in Neuro-psychopharmacology & Biological Psychiatry·G D PrellI M Mazurkiewicz-Kwilecki
Jan 1, 1981·Progress in Neuro-psychopharmacology·G D Prell, I M Mazurkiewicz-Kwilecki
Jan 1, 1980·Pharmacology·N SubramanianC J Estler
Mar 1, 1996·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·S M Zimatkin, K O Lindros
May 1, 1996·Neuroscience and Behavioral Physiology·S M Zimatkin, V F Tsydik
May 27, 1999·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·S M Zimatkin, O V Anichtchik
Feb 13, 2001·Progress in Neurobiology·R E BrownH L Haas
Feb 4, 2003·Nature Reviews. Neuroscience·Helmut Haas, Pertti Panula
Apr 1, 1963·The Journal of Cell Biology·E S REYNOLDS
Jul 31, 2007·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Sergey M Zimatkin, Alexander L Buben
Aug 25, 2007·Brain Structure & Function·K W S Ashwell, G Paxinos
Jul 16, 2008·Physiological Reviews·Helmut L HaasOliver Selbach
Sep 4, 2010·Cellular Signalling·María Gabriela ThomasGraciela Lidia Boccaccio
Sep 25, 2010·The Journal of Pharmacology and Experimental Therapeutics·Pertti Panula, Saara Nuutinen
May 16, 2012·Frontiers in Systems Neuroscience·Patrizio BlandinaMaria B Passani
Jul 6, 2012·Cold Spring Harbor Perspectives in Biology·Carolyn J Decker, Roy Parker