Seven days of muscle re-loading and voluntary wheel running following hindlimb suspension in mice restores running performance, muscle morphology and metrics of fatigue but not muscle strength.

Journal of Muscle Research and Cell Motility
Andrea M HansonV L Ferguson

Abstract

In this study, we examined the effects of 2-week hindlimb un-loading in mice followed by re-ambulation with voluntary access to running wheels. The recovery period was terminated at a time point when physical performance--defined by velocity, time, and distance ran per day--of the suspended group matched that of an unsuspended group. Mice were assigned to one of four groups: unsuspended non-exercise (Control), 14 days of hindlimb suspension (HS), 7 days of access to running wheels (E7), or 14 days of HS plus 7 days access to running wheels (HSE7). HS resulted in significant decreases in body and muscle mass, hindlimb strength, soleus force, soleus specific force, fatigue resistance, and fiber cross sectional area (CSA). Seven days of re-ambulation with access to running wheels following HS recovered masses to Control values, increased fiber CSA, increased resistance to fatigue and improved recovery from fatigue in the soleus. HS resulted in a myosin heavy chain (MHC) phenotype shift from slow toward fast-twitch fibers, though running alone did not influence the expression of MHC fibers. Compared to the Control group, HSE7 mice did not recover functional hindlimb strength as assessed through measurements either in vivo or ex viv...Continue Reading

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Citations

Jun 24, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Yanlei HaoStephen E Alway
Mar 21, 2012·Muscle & Nerve·Louis S StodieckVirginia L Ferguson
Jun 26, 2015·Diabetologia·Vicente Martínez-RedondoJorge L Ruas
Sep 17, 2019·Exercise and Sport Sciences Reviews·Paul T ReidyMicah J Drummond
Jun 20, 2020·Journal of Applied Physiology·Hiroaki EshimaKatsuhiko Funai
Oct 4, 2013·The Journal of Bone and Joint Surgery. American Volume·Chris Hyunchul Jo, Ji Sun Shin

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