Seven in Absentia E3 Ubiquitin Ligases: Central Regulators of Neural Cell Fate and Neuronal Polarity

Frontiers in Cellular Neuroscience
Taren Ong, David J Solecki

Abstract

During neural development, neural precursors transition from a proliferative state within their germinal niches to a migratory state as they relocate to their final laminar positions. Transitions across these states are coupled with dynamic alterations in cellular polarity. This key feature can be seen throughout the developing vertebrate brain, in which neural stem cells give rise to multipolar or unpolarized transit-amplifying progenitors. These transit-amplifying progenitors then expand to give rise to mature neuronal lineages that become polarized as they initiate radial migration to their final laminar positions. The conventional understanding of the cellular polarity regulatory program has revolved around signaling cascades and transcriptional networks. In this review, we discuss recent discoveries concerning the role of the Siah2 ubiquitin ligase in initiating neuronal polarity during cerebellar development. Given the unique features of Siah ubiquitin ligases, we highlight some of the key substrates that play important roles in cellular polarity and propose a function for the Siah ubiquitin proteasome pathway in mediating a post-translational regulatory network to control the onset of polarization.

References

Nov 22, 1994·Proceedings of the National Academy of Sciences of the United States of America·R W CarthewG M Rubin
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A C HartS L Zipursky
Apr 15, 1999·Annual Review of Neuroscience·M E Hatten
Oct 13, 2001·Science·R K Bruick, S L McKnight
Dec 14, 2001·Nature Structural Biology·Galina PolekhinaDavid D L Bowtell
Dec 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·L SusiniA Telerman
Feb 20, 2002·FEBS Letters·Ayaka MaedaToshiyuki Sakai
Mar 9, 2002·Molecular and Cellular Biology·Ross A DickinsDavid D L Bowtell
Nov 2, 2002·The EMBO Journal·Hasem HabelhahZe'ev Ronai
Mar 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Colin M HouseDavid D L Bowtell
Oct 29, 2003·The Journal of Cell Biology·Linton M Traub
Dec 3, 2003·Molecular and Cellular Biology·Ian J FrewDavid D L Bowtell
Feb 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Giusy FiucciAdam Telerman
Oct 12, 2004·Nature Neuroscience·David J SoleckiMary E Hatten
May 11, 2005·Neuron·Li-Huei Tsai, Joseph G Gleeson
Sep 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jonna FrasorBenita S Katzenellenbogen
Oct 19, 2005·The Journal of Biological Chemistry·Zhiheng XuLloyd A Greene
Mar 10, 2006·Journal of Cell Science·Atsushi Suzuki, Shigeo Ohno
Apr 18, 2006·Structure·Colin M HouseGalina Polekhina
Aug 5, 2006·Journal of Cellular Biochemistry·Robert J NadeauRobert Friesel
Sep 28, 2006·The Journal of Biological Chemistry·Ashwani KhuranaZe'ev Ronai
Oct 20, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·David J SoleckiMary E Hatten
Jan 16, 2007·Developmental Biology·Masakazu KadowakiMasatoshi Takeichi
Nov 6, 2007·Developmental Cell·Bob Goldstein, Ian G Macara
Jun 3, 2008·Current Opinion in Neurobiology·Anthony P BarnesFranck Polleux
Jun 10, 2008·Nature Cell Biology·Melanie WinterThomas G Hofmann
Oct 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jianfei QiZe'ev Ronai
Nov 13, 2008·Journal of the National Cancer Institute·Atique U AhmedAmy H Tang
Dec 2, 2008·Nature Cell Biology·Marco A CalzadoM Lienhard Schmitz
Feb 13, 2009·Current Biology : CB·Kevin S Nelson, Greg J Beitel
Jun 16, 2009·Trends in Cell Biology·Richard B ValleeJin-Wu Tsai

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Citations

Apr 1, 2020·Frontiers in Cell and Developmental Biology·Naotaka Nakazawa, Mineko Kengaku
Sep 1, 2019·The Journal of Biological Chemistry·Hyo Rim KoJee-Yin Ahn

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Methods Mentioned

BETA
ubiquitination
two-hybrid
nuclear translocation

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