Seven new veratramine-type alkaloids with potent analgesic effect from Veratrum taliense

Journal of Ethnopharmacology
Qiong LiXiao-Dong Luo

Abstract

Veratrum taliense is traditionally used TCMs in Yunnan province of China for pain and inflammation. Previous research and clinical applications have shown that V. taliense had significant analgesic activity. Jevine-type alkaloids were shown to be one of the anti-inflammatory and analgesic agents from V. taliense. However, other types of compounds from V. taliense related to its traditional use remains unknown. To identify veratramine-type steroidal alkaloids with analgesic effects from the roots and rhizomes of V. taliense. Compounds were isolated from the roots and rhizomes of V. taliense by chromatographic separation. Their structures were elucidated based on UV, IR, NMR and MS spectra data. Analgesic activity was assessed with acetic acid-induced writhing in mice model. Seven new veratramine-type alkaloids were isolated from the roots and rhizomes of V. taliense. They all exhibited significant analgesic activity, of which alkaloids 1 and 4 were more potent antalgic than the well-known analgesic drug, pethidine. The veratramine-type alkaloids from V. taliense may serve as new leads for the discovery of analgesic drugs.

References

Jan 1, 1991·Japanese Journal of Pharmacology·R NagataT Fukuda
Mar 27, 2003·Phytochemistry·M Nadeem AkhtarYoshisuke Tsuda
Jun 24, 2008·Phytotherapy Research : PTR·Jian TangWei-Dong Zhang
Nov 1, 1948·American Heart Journal·E D FREIS, J R STANTON
Mar 25, 2009·Journal of Medicinal Chemistry·Neeraj MahindrooNaoaki Fujii
Jun 26, 2009·Organic Letters·Jeffrey D WinklerNadia Dahmane
Dec 17, 2009·Phytotherapy Research : PTR·Jian TangWei-Dong Zhang
Mar 12, 2010·Journal of Ethnopharmacology·Jian-Hua ShangXiao-Dong Luo
Nov 3, 2010·Annals of Internal Medicine·Alexander K SmithKenneth E Covinsky
Nov 8, 2014·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·Christopher M Chandler, Owen M McDougal
Apr 8, 2015·The Alkaloids. Chemistry and Biology·Philipp Heretsch, Athanassios Giannis
Jan 9, 2016·Journal of Ethnopharmacology·Qiong LiXiao-Dong Luo

❮ Previous
Next ❯

Citations

Dec 29, 2020·Mitochondrial DNA. Part B, Resources·Li-Jun HanGuo-Dong Li
Jun 2, 2021·Natural Product Research·Cuilin HeDonglin Chen
Aug 14, 2020·Journal of Agricultural and Food Chemistry·Wei-Di ChenXiao-Dong Luo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.