Seven novel mammalian SNARE proteins localize to distinct membrane compartments.

The Journal of Biological Chemistry
R J AdvaniR H Scheller

Abstract

Soluble N-ethylmaleimide-sensitive factor-attachment protein receptor (SNARE) proteins of the vesicle-associated membrane protein (VAMP) and syntaxin families play a central role in vesicular trafficking through the formation of complexes between proteins present on vesicle and target membranes. Formation of these complexes is proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. In order to further understand the molecular mechanisms that organize membrane compartments, we have characterized seven new mammalian proteins of the VAMP and syntaxin families. The proteins are broadly expressed; however, syntaxin 13 is enriched in brain and VAMP 8 in kidney. The seven novel SNAREs localize in distinct patterns overlapping with Golgi, endosomal, or lysosomal markers. Our studies support the hypothesis that evolutionary radiation of these two gene families gave rise to sets of proteins whose differential expression and combinatorial associations define and organize the membrane compartments of cells.

References

May 13, 1977·Brain Research·G A Banker, W M Cowan
Sep 10, 1993·Cell·M K BennettR H Scheller
Nov 3, 1994·Nature·J E Rothman
Jan 1, 1994·Annual Review of Biochemistry·M K Bennett, R H Scheller
Jan 1, 1994·Annual Review of Neuroscience·R Jahn, T C Südhof
Mar 25, 1993·Nature·T SöllnerJ E Rothman
Mar 8, 1996·The Journal of Biological Chemistry·J C HayR H Scheller
Jul 26, 1996·The Journal of Biological Chemistry·J B BockR H Scheller
Jan 1, 1996·Methods in Enzymology·A Lupas
May 8, 1997·Nature·J B Bock, R H Scheller
May 8, 1997·Nature·B J NicholsA Haas
Jul 1, 1997·Molecular Biology of the Cell·J B BockR H Scheller
Dec 9, 1997·Neuron·R C Lin, R H Scheller

❮ Previous
Next ❯

Citations

Oct 1, 2005·Histochemistry and Cell Biology·Yohei OishiTaishin Takuma
Oct 17, 2008·Cell and Tissue Research·Namita KanwarGabriele Fischer von Mollard
May 18, 2004·Biology of the Cell·Valeria RossiFrancesco Filippini
Mar 19, 2013·Insect Biochemistry and Molecular Biology·Ashley M VillarrealShahid Karim
Jul 14, 2001·Archives of Oral Biology·A ImaiH Shimomura
Jan 2, 2001·Biology of the Cell·S Martinez-ArcaT Galli
Jul 7, 2001·Trends in Biochemical Sciences·F FilippiniM D'Esposito
Nov 9, 2000·The Plant Journal : for Cell and Molecular Biology·B LeymanM R Blatt
Jun 1, 2006·The Journal of Biological Chemistry·Shadab A SiddiqiCharles M Mansbach
May 31, 2008·The Journal of Biological Chemistry·Stefan SikorraThomas Binz
May 21, 2005·Molecular & Cellular Proteomics : MCP·Maria BarileMark A Knepper
Nov 17, 1999·Molecular Biology of the Cell·R PrekerisR H Scheller
Jun 8, 1999·Molecular Biology of the Cell·M SteegmaierR H Scheller
Sep 3, 1999·Molecular Biology of the Cell·C HolroydR Jahn
Jun 16, 2001·Molecular Biology of the Cell·F WendlerS A Tooze
Jan 27, 2004·Molecular Biology of the Cell·Regina KuliawatPeter Arvan
Jul 4, 2008·Molecular Biology of the Cell·Jason M McEwen, Joshua M Kaplan
Jul 16, 2008·Molecular Biology and Evolution·Tobias H KloepperDirk Fasshauer
Nov 11, 1999·Plant Physiology·A A SanderfootN V Raikhel
Apr 24, 1999·The Plant Cell·A A Sanderfoot, N V Raikhel
Oct 21, 2009·Molecular and Cellular Biology·Cheng-Chun WangWanjin Hong
Jul 16, 2003·Molecular and Cellular Biology·Vadim AtlashkinGabriele Fischer von Mollard
Jun 29, 2000·Annual Review of Biochemistry·R Jahn, T C Südhof
Oct 23, 2003·Annual Review of Cell and Developmental Biology·Paul L McNeil, Richard A Steinhardt
Apr 1, 1999·Annual Review of Physiology·J AveryJ M Edwardson
Jun 10, 2005·BMC Cell Biology·Arja M Band, Esa Kuismanen
Feb 24, 2006·Journal of Cell Science·Shadab A SiddiqiCharles M Mansbach
Jan 14, 2009·Journal of Cell Science·Naava NaslavskySteve Caplan
Sep 10, 2009·Cell Structure and Function·Miki OkayamaTaishin Takuma
Jan 28, 2014·PloS One·Christina M SzalinskiOra A Weisz
Mar 27, 2001·Biochemical and Biophysical Research Communications·H J HoffmannS Nielsen

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.