Seventeen-year antibody persistence in adults primed with two doses of an inactivated hepatitis A vaccine

Human Vaccines & Immunotherapeutics
K Van HerckP Van Damme

Abstract

Antibody persistence and immune memory against hepatitis A (HAV) in adults in a low endemicity country, 15 y after immunisation with two doses of HAV vaccine has been demonstrated. This communication provides additional information on antibody persistence up to Year 17 from two of the longest follow-up studies [NCT00289757/NCT00291876]. In two double-blind primary studies, healthy adults aged 17-40 y and 21-40 y, respectively received two doses of the HAV vaccine following a 0,6 mo or 0,12 mo schedule. Anti-HAV antibody concentrations were measured using an enzyme-linked immunoassay (cut-off: 15 mIU/ml) at Year 16 and Year 17. Subjects who became seronegative (anti-HAV < 15 mIU/ml) since previous reporting were offered a challenge dose, with anti-HAV antibody concentration measurements at Day 14 and Day 30 thereafter. At Year 17, 100% and 96.7% of subjects remained seropositive for anti-HAV antibodies following the 0, 6 mo and 0, 12 mo regimens, respectively (GMCs: 278 mIU/ml and 369 mIU/ml). One subject who became seronegative at Year 16 received a HAV challenge dose within the next 12 mo and mounted an anamnestic response. The challenge dose was well-tolerated. Both HAV immunisation regimens (0,6 mo and 0,12 mo) induced persi...Continue Reading

References

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Citations

Jan 15, 2014·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·D Moreno-PérezUNKNOWN Comité Asesor de Vacunas de la Asociación Española de Pediatría
Oct 28, 2015·Human Vaccines & Immunotherapeutics·Fernando CarlosLuis Romano-Mazzotti
Jan 12, 2016·Human Vaccines & Immunotherapeutics·Fei SuWangxue Chen
Jun 2, 2015·Human Vaccines & Immunotherapeutics·Olivier Van Der MeerenMarc de Ridder
Feb 5, 2015·The Journal of Infectious Diseases·Hannah M Garcia GarridoAbraham Goorhuis
Aug 22, 2012·Current Opinion in Infectious Diseases·Greet HendrickxPierre Van Damme
Jul 28, 2020·Infectious Diseases and Therapy·Ashish AgrawalMonjori Mitra
Aug 3, 2012·Human Vaccines & Immunotherapeutics·Thierry Van EffelterreCinzia Marano

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