Seventeen-Year Journey Working With a Master

Frontiers in Immunology
Jinfang Zhu

Abstract

It had been a great honor for me to work with the late Dr. William E. Paul for 17 years in the Laboratory of Immunology (LI) from 1998 until his passing in 2015. He was such a master in the immunology field. Under his outstanding guidance, my research has been focusing on transcriptional regulation of T helper (Th) cell differentiation, especially, on the role of a master transcription factor GATA3 during Th2 cell differentiation. Just as enormous scientific contributions of Dr. Paul (we all call him Bill) to the immunology community are far beyond his serving as the Chief of the LI, GATA3 also plays important roles in different lymphocytes at various developmental stages besides its critical functions in Th2 cells. In this special review dedicated to the memory of Bill, I will summarize the research that I have carried out in Bill's lab working on GATA3 in the context of related studies by other groups in the field of T cell differentiation and innate lymphoid cell (ILC) development. These include the essential role of GATA3 in regulating Th2/ILC2 differentiation/development and their functions, the critical role of GATA3 during the development of T cells and innate lymphoid cells, and dynamic and quantitative expression of GA...Continue Reading

References

Oct 18, 2000·The Journal of Experimental Medicine·J ZhuW E Paul
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J ZhuW E Paul
Sep 3, 2002·The Journal of Biological Chemistry·Masakatsu YamashitaToshinori Nakayama
Dec 4, 2002·Nature Reviews. Immunology·Kenneth M Murphy, Steven L Reiner
Jul 23, 2003·Immunity·Gabriela Hernández-HoyosJose Alberola-Ila
Feb 11, 2004·Proceedings of the National Academy of Sciences of the United States of America·Sung-Yun PaiI-Cheng Ho
Oct 12, 2004·Nature Immunology·Jinfang ZhuWilliam E Paul
Jan 22, 2005·Science·Eun Sook HwangLaurie H Glimcher
Sep 21, 2005·The Journal of Experimental Medicine·Hidehiro YamaneWilliam E Paul
Oct 3, 2006·Nature Immunology·Christian A J VosshenrichJames P Di Santo
Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter J KimI-Cheng Ho
Nov 23, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jinfang ZhuWilliam E Paul
Jan 5, 2007·Annual Review of Immunology·Casey T WeaverLaurie E Harrington
Apr 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anmol ChandeleSusan M Kaech
Aug 30, 2008·Blood·Jinfang Zhu, William E Paul
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Richard G JennerGraham M Lord
Mar 3, 2010·Annual Review of Immunology·Jinfang ZhuWilliam E Paul
Mar 5, 2010·Nature·Daniel R NeillAndrew N J McKenzie
Mar 26, 2010·Nature Reviews. Immunology·William E Paul, Jinfang Zhu
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·April E PriceRichard M Locksley
Jun 19, 2010·Nature Reviews. Immunology·Shimon SakaguchiDavid A Hafler
Sep 29, 2011·Nature Immunology·Laurel A MonticelliDavid Artis
Oct 4, 2011·The Journal of Clinical Investigation·Elizabeth A WohlfertYasmine Belkaid
Jan 10, 2012·Annual Review of Immunology·Steven Z JosefowiczAlexander Y Rudensky

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Citations

Nov 1, 2020·International Journal of Molecular Sciences·Xiaoliang Zhu, Jinfang Zhu

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Methods Mentioned

BETA
ChIP-Seq
transgenic

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