Several behavioral traits relevant for alcoholism are controlled by ɣ2 subunit containing GABAA receptors on dopamine neurons in mice

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Andrea StojakovicDavid Engblom

Abstract

The risk factors for developing alcohol addiction include impulsivity, high sensitivity to the rewarding action of ethanol, and low sensitivity to its sedative and intoxicating effects. Genetic variation in GABAA receptor subunits, including the ɣ2 subunit (Gabrg2), affects the risk for developing alcoholism. Alcohol directly potentiates GABAA receptors and activates the mesolimbic dopamine system. Here, we deleted Gabrg2 selectively in dopamine cells of adult mice. The deletion resulted in elevated firing of dopamine neurons and made them less sensitive to drugs acting at GABAA receptors. At the behavioral level, the deletion increased exploratory behavior and augmented both correct and incorrect responding in the go/no-go task, a test often used to assay the response inhibition component of impulsivity. In addition, conditioned place preference to alcohol, but not to cocaine or morphine, was increased. Ethanol-induced locomotor activation was enhanced in the mice lacking Gabrg2 on dopaminergic cells, whereas the sedative effect of alcohol was reduced. Finally, the alcohol drinking, but not the alcohol preference, at a high concentration was increased in the mutant mice. In summary, deletion of Gabrg2 on dopamine cells induced...Continue Reading

References

Jan 1, 1992·Psychopharmacology·C L CunninghamL K Prather
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·G Di Chiara, A Imperato
Feb 1, 1987·Neuropharmacology·M K MenonK Von Hungen
Feb 1, 1995·Alcoholism, Clinical and Experimental Research·R A HarrisT V Dunwiddie
Mar 1, 1996·Journal of Studies on Alcohol·L Hilakivi-Clarke
Oct 13, 1998·Psychopharmacology·R R KohlW J McBride
Dec 11, 1999·Alcoholism, Clinical and Experimental Research·M S BrodieS B Appel
Jul 16, 2002·Nature Neuroscience·Inger Sundstrom-PoromaaSheryl S Smith
Jun 27, 2003·Synapse·Isabelle BoileauAlain Dagher
Oct 24, 2003·Molecular and Cellular Neurosciences·Claude SchweizerBernhard Lüscher
Nov 20, 2003·Proceedings of the National Academy of Sciences of the United States of America·M WallnerR W Olsen
Mar 20, 2004·Journal of Neurochemistry·Hideki OkadaKazuto Kobayashi
Nov 16, 2006·PLoS Medicine·Christian Lüscher, Mark A Ungless
Dec 5, 2006·European Journal of Pharmacology·Elin LöfBo Söderpalm
Dec 8, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lionel DahanGuy Chouvet
Mar 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Kole RoybalColleen A McClung
Apr 5, 2007·Nature Protocols·Alicia A Walf, Cheryl A Frye
Jul 18, 2008·Science Signaling·R Adron HarrisS John Mihic
Mar 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Matthew T C BrownPeter J Magill
Jan 30, 2010·Psychopharmacology·Annika ThorsellMarkus Heilig
Feb 13, 2010·Addiction Biology·Danielle M DickKenneth Sher
May 19, 2010·Molecular Psychiatry·V A RamchandaniM Heilig
Jan 14, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Claus RiekerRosanna Parlato
Apr 6, 2011·Archives of General Psychiatry·Andrea C KingDingcai Cao
Jul 19, 2011·Alcoholism, Clinical and Experimental Research·Marc A SchuckitGeorge Davey-Smith
Jan 17, 2012·Physiology & Behavior·Mu YangJacqueline N Crawley
Mar 31, 2012·Trends in Neurosciences·Mark A Ungless, Anthony A Grace
Jun 1, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Angela Renee OzburnColleen A McClung
Oct 15, 2013·Alcoholism, Clinical and Experimental Research·Jordan T YorgasonSara R Jones
Oct 19, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dawei LiJoel Gelernter
Mar 20, 2014·The Journal of Pharmacology and Experimental Therapeutics·Nathan D SchilatyScott C Steffensen
Jun 21, 2014·Cell·Lisa A GunaydinKarl Deisseroth
Aug 1, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Katalin Kerti-SzigetiMark D Eyre

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Citations

Sep 8, 2018·Frontiers in Cellular Neuroscience·Joshua M Lorenz-GuertinTija C Jacob
Feb 9, 2021·Frontiers in Nutrition·Jian HanAntoniette M Maldonado-Devincci

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Methods Mentioned

BETA
transgenic
sedation

Software Mentioned

EthoVision

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