Several Follicular Regulatory T Cell Subsets With Distinct Phenotype and Function Emerge During Germinal Center Reactions

Frontiers in Immunology
Nicolas Fazilleau, Meryem Aloulou

Abstract

An efficient B cell immunity requires a dynamic equilibrium between positive and negative signals. In germinal centers (GCs), T follicular helper cells are supposed to be the positive regulator while T follicular regulatory (Tfr) cells were assigned to be the negative regulators. Indeed, Tfr cells are considered as a homogenous cell population dedicated to dampen the GC extent. Moreover, Tfr cells prevent autoimmunity since their dysregulation leads to production of self-reactive antibodies (Ab). However, a growing corpus of evidence has revealed additional and unexpected functions for Tfr cells in the regulation of B cell responses. This review provides an overview of the Tfr cell contribution and presents Tfr cell proprieties in the context of vaccination.

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Citations

Mar 16, 2019·Immunological Reviews·Wataru Ise, Tomohiro Kurosaki
May 17, 2019·The Journal of Clinical Endocrinology and Metabolism·Xinyu XuTao Yang
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Apr 4, 2021·Immunology Letters·Fanny MartinezMeryem Aloulou

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