PMID: 7513341Feb 1, 1994Paper

Several insulin-like growth factor-I analogues and complexes of insulin-like growth factors-I and -II with insulin-like growth factor-binding protein-3 fail to mimic the effect of growth hormone upon lactation in the rat

The Journal of Endocrinology
D FlintM Gardner

Abstract

Lactation was suppressed in rats using a combined treatment of bromocriptine (to reduce prolactin concentrations) and a specific antiserum to rat GH administered twice daily for 2 days. When milk production had ceased, as determined by litter weight loss and the absence of milk in the stomachs of pups, attempts were made to reinitiate lactation using prolactin, GH, insulin-like growth factor-I (IGF-I) precomplexed to recombinant human IGF-binding protein-3 (hIGFBP-3) or IGF-I plus IGF-II precomplexed to hIGFBP-3. Despite the fact that all treatments except prolactin led to increases in serum IGFs and IGFBP-3, only prolactin and GH provoked the reinitiation of milk production as determined by increased litter weight gain, milk in the stomach of pups and a significant increase in the weight of the mammary glands. Since the mammary gland has been shown to produce IGFBPs which may inhibit IGF action we also tested three IGF-I analogues, R3-IGF-I, Long-IGF-I and Long-R3-IGF-I. R3-IGF-I has a single amino acid substitution (Glu to Arg) at position 3 whereas Long-IGF-I has a 13 amino acid N-terminal extension. These modifications dramatically reduce the ability of these analogues to bind to IGFBPs although they remain active at the IG...Continue Reading

Citations

Jun 2, 2011·Disease Models & Mechanisms·Sebastien ElisShoshana Yakar
Jun 12, 2012·Endocrinology and Metabolism Clinics of North America·Shoshana Yakar, Martin L Adamo
May 20, 1998·In Vitro Cellular & Developmental Biology. Animal·N IlanM Shani
Jan 1, 1996·Journal of Mammary Gland Biology and Neoplasia·C J Wilde, W L Hurley
May 19, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A M Di GiulioA Gorio
Oct 31, 2002·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Alan B G Lansdown
May 18, 2020·Cancers·Divya Thomas, Prakash Radhakrishnan
May 3, 2000·Journal of Dairy Science·H A Tucker
Aug 19, 2007·Alimentary Pharmacology & Therapeutics·J ShenS D Xiao
Oct 30, 2010·Journal of Cellular and Molecular Medicine·M Rita LeccaThierry Hennet
Jul 9, 1999·Journal of Neuroscience Research·A Fex Svenningsen, M Kanje

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