Several Routes to the Same Destination: Inhibition of Phagosome-Lysosome Fusion by Mycobacterium tuberculosis

The American Journal of the Medical Sciences
Claudia Carranza, Leslie Chavez-Galan

Abstract

Phagocytosis is necessary for antigen degradation and presentation, the activation of the adaptive immune response and the elimination of pathogenic micro-organisms. The phagosomal vacuole formed during phagocytosis requires a process of maturation that involves fusion with lysosomes, a decrease in luminal pH and the activation of the enzymes that eventually will destroy phagocytized micro-organisms. Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. This agent has developed various strategies to prevent phagosome maturation and persist indefinitely in latency mode. Herein, we review these strategies in the light of available experimental evidence. A better understanding of them may be essential in the development of more effective therapies against tuberculosis.

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Citations

May 24, 2019·Infection·William OglesbyJorge L Cervantes
Jun 20, 2020·Antioxidants & Redox Signaling·Eduardo P AmaralBruno B Andrade
Jun 17, 2020·The Journal of Cell Biology·Helen Weavers, Paul Martin
Jul 31, 2020·Cellular & Molecular Immunology·Qiyao ChaiBaoxue Ge
May 4, 2021·Frontiers in Microbiology·Julio FloresLeslie Chavez-Galan
Jun 12, 2021·Frontiers in Immunology·Tamiris Lameira BittencourtRoberta Olmo Pinheiro

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