Severe acne vulgaris and tobacco smoking in young men

The Journal of Investigative Dermatology
Itay KlazSarah Brenner

Abstract

As the relationship between tobacco smoking and acne remains unclear, we examined the relationship between cigarette smoking and severe acne in a large cohort of young men. Trained nurses interviewed subjects upon discharge from compulsory military service, regarding family history, habits, and tobacco smoking habits. Data was correlated with severe acne status, as diagnosed and coded by board-certified dermatologists. In total, 27,083 male subjects participated in the study from 1983 to 2003, of which 237 (0.88%) had severe acne, 11,718 (43.27%) were active smokers, and 15,365 (56.73%) were nonsmokers at the time of interviews. Active smokers showed a significantly lower prevalence of severe acne (0.71%) than nonsmokers (1.01%) (P = 0.0078). An inverse dose-dependent relationship between severe acne prevalence and daily cigarette consumption became significant from 21 cigarettes a day (chi2 and trend test: P < 0.0001), odds ratio: 0.2 (95% CI: 0.06-0.63). The study did not aim to establish a temporal correlation, and passive smoking and acne treatments were not measured. Previous in vitro and clinical studies strongly support an association with nicotine. We suggest a trial with topical nicotine treatment for acne to further i...Continue Reading

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Citations

Jul 14, 2010·Journal of Neuroinflammation·Lorise C GahringScott W Rogers
Mar 6, 2012·Journal of the American Academy of Dermatology·Anna Di LandroUNKNOWN GISED Acne Study Group
Sep 2, 2011·Lancet·Hywel C WilliamsSarah Garner
Jul 14, 2010·Journal of the American Academy of Dermatology·Bruno CapitanioChristos C Zouboulis
Mar 14, 2009·The Journal of Investigative Dermatology·S Zahra GhodsiChristos C Zouboulis
May 14, 2008·Experimental Dermatology·Christos C ZouboulisAnja Thielitz
Jan 29, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·L M H RehnM Henriksson
Feb 22, 2012·International Journal of Dermatology·Arisa Ortiz, Sergei A Grando
Dec 6, 2012·The British Journal of Dermatology·K Bhate, H C Williams
May 21, 2011·International Journal of Dermatology·Dae Hun SuhKwang Joong Kim
May 4, 2010·Dermato-endocrinology·Bruno CapitanioM Picardo
Jan 30, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·B DrénoA Bouloc
May 21, 2011·Dermatology : International Journal for Clinical and Investigative Dermatology·Gregor B E Jemec
Jul 15, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·P WolkensteinA Delarue
Oct 18, 2016·The Journal of the Egyptian Public Health Association·Nagah M Abo El-FetohOmar G Alenezi
Apr 3, 2020·Scientific Reports·Anna Hwee Sing Heng, Fook Tim Chew
May 16, 2014·Deutsches Ärzteblatt International·Harald P Gollnick, Christos C Zouboulis
Jun 7, 2018·International Journal of Women's Dermatology·A U TanA S Paller

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