Severe Acute Kidney Injury and Mortality in Extremely Low Gestational Age Neonates.

Clinical Journal of the American Society of Nephrology : CJASN
Sangeeta HingoraniPENUT Investigators

Abstract

AKI is associated with poor short- and long-term outcomes. Questions remain about the frequency and timing of AKI, and whether AKI is a cause of death in extremely low gestational age neonates. The Recombinant Erythropoietin for Protection of Infant Kidney Disease Study examines the kidney outcomes of extremely low gestational age neonates enrolled in the Preterm Epo Neuroprotection study, a randomized, placebo-controlled trial of recombinant human erythropoietin. We included 900 of 941 patients enrolled in Preterm Epo Neuroprotection. Baseline characteristics were compared by primary exposure (severe AKI versus none/stage 1 AKI) using unadjusted logistic regression models. Cox regression models estimated the relationship between severe AKI and death after adjustment for potential confounders. Time-dependent AKI was modeled as a binary outcome and a categorical variable by stage of AKI. We fit Cox models using time-dependent AKI status lagged by <7 days before death. Landmark analyses examined the relationship of death with development of severe AKI. Severe AKI occurred in 168 of 900 (19%, 95% confidence interval, 17% to 20%) neonates, and stage 3 AKI occurred in 60 (7%, 95% confidence interval, 5% to 8%). Stage 3 AKI occurring...Continue Reading

References

Jan 10, 2001·The Journal of Pediatrics·D K RichardsonS K Lee
Sep 28, 2002·Critical Care Medicine·John A Kellum, Derek C Angus
Mar 31, 2007·Kidney International·A Akcan-ArikanS L Goldstein
Jun 26, 2007·Critical Care : the Official Journal of the Critical Care Forum·Sean M BagshawUNKNOWN ANZICS Database Management Committee
Apr 18, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Michael ZappitelliStuart L Goldstein
Sep 20, 2008·Nephron. Clinical Practice·Shigehiko Uchino
Feb 25, 2009·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·David J AskenaziNamasivayam Ambalavanan
Jul 18, 2009·Archives of Disease in Childhood. Fetal and Neonatal Edition·B N ManktelowD J Field
Dec 24, 2010·Pediatric Research·Rajesh KoralkarDavid Askenazi
Aug 3, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Sreekanth ViswanathanMaroun J Mhanna
Jan 1, 2015·Maternal Health, Neonatology and Perinatology·Sandra E JuulPatrick J Heagerty
May 8, 2018·The Lancet Child & Adolescent Health·Jennifer G JettonUNKNOWN Neonatal Kidney Collaborative (NKC)
Jun 6, 2018·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mohamed A ShalabyJameela A Kari
Dec 14, 2018·Pediatric Research·Jennifer R CharltonUNKNOWN Neonatal Kidney Collaborative (NKC)
Nov 19, 2019·Clinical Journal of the American Society of Nephrology : CJASN·Jennifer R CharltonUNKNOWN Neonatal Kidney Collaborative
Jan 16, 2020·The New England Journal of Medicine·Sandra E JuulUNKNOWN PENUT Trial Consortium
Jun 4, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·David J AskenaziUNKNOWN PENUT Trial Consortium
Jun 12, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Salimah R Walani
Sep 7, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Matthew W HarerDavid J Askenazi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.