Dec 6, 2014

Severe acute malnutrition and infection

Paediatrics and International Child Health
Kelsey D J Jones, James A Berkley

Abstract

Severe acute malnutrition (SAM) is associated with increased severity of common infectious diseases, and death amongst children with SAM is almost always as a result of infection. The diagnosis and management of infection are often different in malnourished versus well-nourished children. The objectives of this brief are to outline the evidence underpinning important practical questions relating to the management of infectious diseases in children with SAM and to highlight research gaps. Overall, the evidence base for many aspects covered in this brief is very poor. The brief addresses antimicrobials; antipyretics; tuberculosis; HIV; malaria; pneumonia; diarrhoea; sepsis; measles; urinary tract infection; nosocomial Infections; soil transmitted helminths; skin infections and pharmacology in the context of SAM. The brief is structured into sets of clinical questions, which we hope will maximise the relevance to contemporary practice.

  • References152
  • Citations28

Mentioned in this Paper

Septicemia
Tuberculosis
Medical Research Activity
Urinary Tract Infection
Helminths
Malaria
Malaria Vaccines
Malnutrition
Teens
Deal Barratt Dillon Syndrome

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