PMID: 8589617Dec 1, 1995Paper

Severe acute regional toxicity after normothermic or 'mild' hyperthermic isolated limb perfusion with melphalan for melanoma

Melanoma Research
Bart C VrouenraetsJ A van Dongen

Abstract

Incidence, nature and cause of severe acute regional toxicity were studied in 181 patients who underwent normothermic (37-38 degrees C) or 'mild' hyperthermic (38-40 degrees C) isolated limb perfusion (ILP) with melphalan. The known risk factors for toxicity (sex, tissue temperature, blood gas values, isolation level and melphalan peak concentration) were analysed. Severe acute regional toxicity occurred in 30 patients (16%). The limb was painful, swollen, red and warm in 19, often with a smooth and glistening aspect. Blistering scattered over the extremity was seen in 11 cases. In another 11 patients, late blistering limited to the footsole or handpalm developed. Twenty-six patients with severe toxicity had undergone ILP at the iliac isolation level (p < 0.05). Sex and tissue temperature did not predict toxicity. Venous perfusate blood gas values were severely deteriorated in four patients; high calculated melphalan peak concentrations occurred in nine patients. Irreversible long-term morbidity as a sequence of severe toxicity occurred in 10 of the 30 patients. Only one of the 11 patients with late blisters limited to sole or palm developed long-term morbidity (p < 0.05). Thus, the only risk factor for severe acute regional to...Continue Reading

Citations

Jan 1, 1997·Annals of Surgical Oncology·B C VrouenraetsJ A van Dongen
Apr 9, 2008·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Merrick I Ross
Apr 9, 2008·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Mecker G MöllerJonathan S Zager
May 10, 2011·Current Problems in Surgery·Amira SankiJohn F Thompson
Aug 30, 2008·Surgical Oncology Clinics of North America·Bin B R KroonOmgo E Nieweg
Apr 25, 2006·Surgical Oncology Clinics of North America·Eva M NoordaBin B R Kroon
Jan 24, 2014·Journal of Surgical Oncology·Claire F Temple-OberleJ Gregory McKinnon
Jan 15, 2014·Journal of Surgical Oncology·Omgo E Nieweg, Bin B R Kroon
Dec 8, 1998·Journal of the American Academy of Dermatology·M LandauM Gutman
Jun 22, 2001·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·B C VrouenraetsB B Kroon
Oct 21, 1999·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·B C VrouenraetsB B Kroon
Nov 7, 2002·The Journal of Veterinary Medical Science·Toshifumi YokoyamaYasuyuki Kannan
May 9, 2003·The Journal of Veterinary Medical Science·Toshifumi YokoyamaYasuyuki Kannan
Apr 21, 1998·Seminars in Surgical Oncology·B C VrouenraetsB B Kroon
May 11, 1999·Journal of the American College of Surgeons·B C VrouenraetsB B Kroon

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