Severe acute respiratory syndrome coronavirus-2 and the deduction effect of angiotensin-converting enzyme 2 in pregnancy.

Journal of the Chinese Medical Association : JCMA
Yu-Ju LaiCheng-Chang Chang

Abstract

The 2019 novel coronavirus (2019-nCoV, later named SARS-CoV-2) is a pandemic disease worldwide. The spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is continuing at a rapid speed. Till May 4, 2020, there have been 3,407,747 confirmed cases and 238,198 deaths globally. The common symptoms in pregnant women are fever, cough, and dyspnea. Angiotensin-converting enzyme 2 (ACE2) has transient overexpression and increased activity during pregnancy, which is now confirmed as the receptor of SARS-CoV-2 and plays essential roles in human infection and transmission. There is no evidence that pregnant women are more susceptible to SARS-CoV-2. To date, there is no valid medication or vaccination. The immune suppression or modulation during pregnancy increases the risk of severe pneumonia. Remdesivir is an antiviral medication targeting ribonucleic acid (RNA) synthesis that has clinical improvement in the treatment of SARS-CoV-2. Chloroquine is controversial in its effectiveness and safety to treat SARS-CoV-2. Remdesivir is safe in pregnancy. Chloroquine has not been formally assigned to a pregnancy category by the Food and Drug Administration (FDA). The management strategy includes monitoring fetal heart rate and ute...Continue Reading

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Citations

Oct 4, 2020·Journal of the Chinese Medical Association : JCMA·Hsin-Hui HuangCheng-Chang Chang
Feb 13, 2021·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Carlos Saus-Ortega
Aug 10, 2021·Journal of the Chinese Medical Association : JCMA·Peng-Hui WangFa-Kung Lee
Aug 10, 2021·Journal of the Chinese Medical Association : JCMA·Wen-Ling LeePeng-Hui Wang
Aug 26, 2021·Journal of the Chinese Medical Association : JCMA·Peng-Hui WangFa-Kung Lee

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Methods Mentioned

BETA
cesarean section

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