Severe acute respiratory syndrome coronavirus-2 natural animal reservoirs and experimental models: systematic review.

Reviews in Medical Virology
Salma YounesGheyath K Nasrallah

Abstract

The current severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) outbreak has been rapidly spreading worldwide, causing serious global concern. The role that animal hosts play in disease transmission is still understudied and researchers wish to find suitable animal models for fundamental research and drug discovery. In this systematic review, we aimed to compile and discuss all articles that describe experimental or natural infections with SARS-CoV-2, from the initial discovery of the virus in December 2019 through to October 2020. We systematically searched four databases (Scopus, PubMed, Science Direct and Web of Science). The following data were extracted from the included studies: type of infection (natural or experimental), age, sample numbers, dose, route of inoculation, viral replication, detection method, clinical symptoms and transmission. Fifty-four studies were included, of which 34 were conducted on animal reservoirs (naturally or experimentally infected), and 20 involved models for testing vaccines and therapeutics. Our search revealed that Rousettus aegyptiacus (fruit bats), pangolins, felines, mink, ferrets and rabbits were all susceptible to SARS-CoV-2, while dogs were weakly susceptible and pigs, poult...Continue Reading

References

Mar 20, 2004·Emerging Infectious Diseases·Hana M WeingartlMarkus Czub
Mar 1, 2007·Emerging Infectious Diseases·Lin-Fa WangBryan T Eaton
May 15, 2007·Virus Research·Anjeanette RobertsKanta Subbarao
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Jul 18, 2015·Current Opinion in Virology·Lisa M Gretebeck, Kanta Subbarao
Feb 13, 2016·Frontiers in Microbiology·Ding Y Oh, Aeron C Hurt
Jul 22, 2017·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Ricki J Colman
Dec 12, 2018·Nature Reviews. Microbiology·Jie CuiZheng-Li Shi
Mar 6, 2019·Viruses·Yi FanPeng Zhou
Jan 19, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·David S HuiEskild Petersen
Jan 23, 2020·Journal of Medical Virology·Wei JiXingguang Li
Mar 19, 2020·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Kenji MizumotoGerardo Chowell
Mar 21, 2020·Current Biology : CB·Tao ZhangZhigang Zhang
Mar 29, 2020·Nature·Tommy Tsan-Yuk LamWu-Chun Cao
Apr 3, 2020·Nature·Smriti Mallapaty
Apr 8, 2020·Cell Host & Microbe·Young-Il KimYoung Ki Choi
Apr 9, 2020·Emerging Infectious Diseases·Nisreen M A OkbaBart L Haagmans
Apr 12, 2020·Clinical Rheumatology·Durga Prasanna MisraOlena Zimba
Apr 15, 2020·Nature Medicine·Kristian G AndersenRobert F Garry
Apr 23, 2020·Animal Models and Experimental Medicine·Pin YuChuan Qin
May 8, 2020·Nature·Linlin BaoChuan Qin
May 13, 2020·The Veterinary Quarterly·Ruchi TiwariAlfonso J Rodriguez-Morales
May 14, 2020·The New England Journal of Medicine·Peter J HalfmannYoshihiro Kawaoka
May 14, 2020·Veterinary Microbiology·Nicola Decaro, Alessio Lorusso
May 15, 2020·Nature·Thomas H C SitMalik Peiris
May 15, 2020·Nature·Sin Fun SiaHui-Ling Yen
May 18, 2020·Cell·Daniel Blanco-MeloBenjamin R tenOever
May 22, 2020·Science·Jingyou YuDan H Barouch
May 22, 2020·Science·Abishek ChandrashekarDan H Barouch
May 30, 2020·Viruses·Nadin YounesGheyath K Nasrallah
May 31, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jasper Fuk-Woo ChanKwok-Yung Yuen
Jun 3, 2020·Cell Host & Microbe·Shi-Hui SunYou-Chun Wang

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Citations

Jan 22, 2021·Expert Opinion on Therapeutic Patents·Ilaria VicentiFrancesco Saladini
Apr 25, 2021·The Veterinary Quarterly·Khan SharunYoussef A Attia
Jul 22, 2021·Emerging Infectious Diseases·Angela M Bosco-LauthRichard A Bowen
Aug 8, 2021·Animals : an Open Access Journal From MDPI·Kimberly EkstrandKathleen N Morgan
Aug 7, 2021·Journal of Medical Microbiology·Farah M ShurrabGheyath K Nasrallah

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Methods Mentioned

BETA
ELISA
transgenic

Software Mentioned

Prisma
Endnote X9

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