Severe acute respiratory syndrome coronavirus 2 infection reaches the human nervous system: How?

Journal of Neuroscience Research
Vladimir N. UverskyElrashdy M Redwan

Abstract

Without protective and/or therapeutic agents the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection known as coronavirus disease 2019 is quickly spreading worldwide. It has surprising transmissibility potential, since it could infect all ages, gender, and human sectors. It attacks respiratory, gastrointestinal, urinary, hepatic, and endovascular systems and can reach the peripheral nervous system (PNS) and central nervous system (CNS) through known and unknown mechanisms. The reports on the neurological manifestations and complications of the SARS-CoV-2 infection are increasing exponentially. Herein, we enumerate seven candidate routes, which the mature or immature SARS-CoV-2 components could use to reach the CNS and PNS, utilizing the within-body cross talk between organs. The majority of SARS-CoV-2-infected patients suffer from some neurological manifestations (e.g., confusion, anosmia, and ageusia). It seems that although the mature virus did not reach the CNS or PNS of the majority of patients, its unassembled components and/or the accompanying immune-mediated responses may be responsible for the observed neurological symptoms. The viral particles and/or its components have been specifically documented i...Continue Reading

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Citations

May 3, 2021·Acta neurologica Belgica·Zahra Shabani
Jul 28, 2021·Neurological Research and Practice·Yana Leven, Julian Bösel
Aug 8, 2021·Journal of Clinical Medicine·Hashir Ali AwanDomenico De Berardis
Oct 6, 2021·Nature Communications·Marion FerrenCyrille Mathieu

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Methods Mentioned

BETA
transmission electron microscopy
biopsy
transgenic
electron microscopy
bronchoalveolar lavage
PCR
electrophoresis
biopsies

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