PMID: 14629957Nov 25, 2003Paper

Severe acute respiratory syndrome (SARS) in children: epidemiology, presentation and management

Paediatric Respiratory Reviews
T F LeungT F Fok

Abstract

Severe acute respiratory syndrome (SARS) is a newly recognised and highly contagious respiratory infection caused by a new strain of coronavirus. The disease can result in progressive respiratory failure in adults and the mortality rate has been reported to be 8-15%. This infection spreads by droplet transmission and children appear to acquire SARS through close household contact exposure to infected adults. Disease severity is, however, much milder in the paediatric age group. The common laboratory findings in infected children and adolescents include lymphopaenia and elevated levels of lactate dehydrogenase and creatinine phosphokinase. Air space consolidation is commonly seen during the course of the illness although chest radiographs are normal on presentation in half of the cases. The pathophysiology of SARS appears to be related to immunological dysregulation in response to the coronavirus infection. The optimal treatment of SARS in children remains to be determined. No case fatality in infected children has been reported. The early and proper isolation of infected adults, meticulous infection control measures in the hospital setting, exhaustive contact tracing and quarantine measures are important steps in preventing the...Continue Reading

References

Apr 3, 2003·The New England Journal of Medicine·Susan M PoutanenUNKNOWN Canadian Severe Acute Respiratory Syndrome Study Team
Apr 3, 2003·The New England Journal of Medicine·Kenneth W TsangKar N Lai
Apr 16, 2003·The New England Journal of Medicine·Nelson LeeJoseph J Y Sung
Apr 12, 2003·The New England Journal of Medicine·Thomas G KsiazekUNKNOWN SARS Working Group
Apr 25, 2003·Lancet·J S M PeirisUNKNOWN SARS study group
May 6, 2003·Science·Marco A MarraRachel L Roper
May 8, 2003·JAMA : the Journal of the American Medical Association·Christopher M BoothAllan S Detsky
May 28, 2003·Lancet·Dale A FisherPaul A Tambyah
Jun 5, 2003·Lancet·John M NichollsJ S Malik Peiris
Jun 21, 2003·BMJ : British Medical Journal·Raymond S M WongJoseph J Y Sung
Jul 2, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Wa-keung ChiuW M Lai

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Citations

Jul 4, 2013·Travel Medicine and Infectious Disease·K L Hon
Jan 22, 2005·Respiratory Research·David A GronebergPeter Zabel
Apr 12, 2006·PLoS Medicine·James V LawlerJason Paragas
Oct 22, 2004·Emerging Infectious Diseases·Johannes BrugGeorge D Bishop
Sep 24, 2009·Pediatric Pulmonology·K L Hon
Jul 9, 2013·The Clinical Respiratory Journal·Kam Lun Ellis Hon, Ting Fan Leung
Feb 10, 2006·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Siu Pui LamHo Pui So
Aug 4, 2006·Psychiatry and Clinical Neurosciences·Chih-Hung KoMing-Jen Yang
Oct 24, 2006·Risk Analysis : an Official Publication of the Society for Risk Analysis·Seonghoon Hong, Alan Collins
Apr 2, 2004·The British Journal of Psychiatry : the Journal of Mental Science·Sammy Kin-Wing ChengYin-Kwok Ng
Jan 8, 2005·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Gabriel M LeungTai-Hing Lam
Jan 8, 2005·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Arjun SrinivasanUNKNOWN SARS Healthcare Preparedness and Response Plan Team
Apr 11, 2018·Disaster Medicine and Public Health Preparedness·Erin SmithCécile Bensimon
Sep 30, 2010·The Tohoku Journal of Experimental Medicine·Tatsuhiko SuzukiKenichi Kida
Jun 29, 2011·Letters in Applied Microbiology·T M KorvesG M Hwang
Feb 18, 2005·Emerging Infectious Diseases·David KohSin-Eng Chia
Aug 13, 2004·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Roy M AndersonAnthony J Hedley
Mar 4, 2014·Pathogens and Disease·Shauna Milne-PriceVincent J Munster
Apr 8, 2020·Pediatric Pulmonology·Qinxue ShenHong Peng
Jun 12, 2020·Seminars in Thrombosis and Hemostasis·Paul F LindholmHau C Kwaan
Nov 14, 2020·Journal of Pediatric Nursing·Elahe Aleebrahim-DehkordiNima Rezaei
Feb 9, 2021·International Archives of Otorhinolaryngology·Pietro BertiniFabio Guarracino
Jul 6, 2021·Frontiers in Pediatrics·Cecilia PerretJose A Castro-Rodriguez
Jul 14, 2021·Journal of Racial and Ethnic Health Disparities·Sanjana KurupDexter L Lee

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