PMID: 14629957Nov 25, 2003Paper

Severe acute respiratory syndrome (SARS) in children: epidemiology, presentation and management

Paediatric Respiratory Reviews
T F LeungT F Fok


Severe acute respiratory syndrome (SARS) is a newly recognised and highly contagious respiratory infection caused by a new strain of coronavirus. The disease can result in progressive respiratory failure in adults and the mortality rate has been reported to be 8-15%. This infection spreads by droplet transmission and children appear to acquire SARS through close household contact exposure to infected adults. Disease severity is, however, much milder in the paediatric age group. The common laboratory findings in infected children and adolescents include lymphopaenia and elevated levels of lactate dehydrogenase and creatinine phosphokinase. Air space consolidation is commonly seen during the course of the illness although chest radiographs are normal on presentation in half of the cases. The pathophysiology of SARS appears to be related to immunological dysregulation in response to the coronavirus infection. The optimal treatment of SARS in children remains to be determined. No case fatality in infected children has been reported. The early and proper isolation of infected adults, meticulous infection control measures in the hospital setting, exhaustive contact tracing and quarantine measures are important steps in preventing the...Continue Reading


Apr 3, 2003·The New England Journal of Medicine·Susan M PoutanenUNKNOWN Canadian Severe Acute Respiratory Syndrome Study Team
Apr 3, 2003·The New England Journal of Medicine·Kenneth W TsangKar N Lai
Apr 16, 2003·The New England Journal of Medicine·Nelson LeeJoseph J Y Sung
Apr 12, 2003·The New England Journal of Medicine·Thomas G KsiazekUNKNOWN SARS Working Group
Apr 25, 2003·Lancet·J S M PeirisUNKNOWN SARS study group
May 6, 2003·Science·Marco A MarraRachel L Roper
May 8, 2003·JAMA : the Journal of the American Medical Association·Christopher M BoothAllan S Detsky
May 28, 2003·Lancet·Dale A FisherPaul A Tambyah
Jun 5, 2003·Lancet·John M NichollsJ S Malik Peiris
Jun 21, 2003·BMJ : British Medical Journal·Raymond S M WongJoseph J Y Sung
Jul 2, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Wa-keung ChiuW M Lai

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Apr 12, 2006·PLoS Medicine·James V LawlerJason Paragas
Oct 22, 2004·Emerging Infectious Diseases·Johannes BrugGeorge D Bishop
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