Severe acute respiratory syndrome (SARS) coronavirus: application of monoclonal antibodies and development of an effective vaccine

Reviews in Medical Virology
Yasuko Tsunetsugu-YokotaToshitada Takemori

Abstract

SARS-CoV is a new type of human coronavirus identified as a causative agent of severe acute respiratory syndrome (SARS). On the occasion of the SARS outbreak, various monoclonal antibodies (mAbs) against SARS-CoV have been developed and applied for diagnosis, clinical management and basic research. In this review, we overview the biochemical and functional properties and applications of these SARS-CoV mAbs. We also focus on a variety of vaccines currently under development and discuss the immune response elicited by these vaccines in animal models, hopefully to better understand what we need to do next to fight against newly emerging pathogens in the future.

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Citations

Mar 6, 2007·Bioorganic & Medicinal Chemistry Letters·Masahiro IkejiriTokumi Maruyama
Jan 21, 2016·Antimicrobial Agents and Chemotherapy·Tatiana BaranovichElena A Govorkova
Aug 28, 2020·Frontiers in Immunology·Vibhuti Kumar ShahSamit Chattopadhyay
Jul 22, 2020·Journal of Medical Virology·Yunfei WangCunbao Liu
Jan 12, 2021·Frontiers in Immunology·Jing ZhaoQiwei Zhang
Aug 18, 2021·Virologica Sinica·Jiang-Fan LiCheng-Feng Qin

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