Severe adverse drug reactions

Clinical Medicine : Journal of the Royal College of Physicians of London
Ying Xin Teo, S A Walsh

Abstract

Severe cutaneous adverse reactions (SCARs) can present in a multitude of ways including Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms, and acute generalised exanthematous pustulosis. While the prognosis and therapy for these conditions may vary, it is crucial that the culprit drug is identified and withheld early as this can influence patient outcome. Mainstay of management is by supportive therapy. In all SCARs, long-term sequelae which may not be apparent initially can be debilitating and cause lasting impact on the quality of life of survivors.

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Citations

Jan 21, 2019·Allergy, Asthma & Immunology Research·Hea Lin OhUNKNOWN Korean Severe Cutaneous Adverse Reactions Consortium
Nov 7, 2019·Current Pharmaceutical Design·Eva Rebelo GomesFrederico Regateiro
Nov 23, 2017·International Journal of Dermatology·Rokea A El-AzharyLaTonya J Hickson

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