Severe adverse skin reactions to nonsteroidal antiinflammatory drugs: A review of the literature

American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
Kristina E WardTracey L Mersfelder

Abstract

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) associated with the use of nonsteroidal antiinflammatory drugs (NSAIDs) are described. A search of the English- language medical literature was conducted to identify studies and cases of SJS and TEN associated with NSAIDs and cyclooxygenase-2-selective NSAIDs available in the United States. Several epidemiologic studies, case reports, and case series involving SJS and TEN associated with NSAIDs were identified. Of the available NSAIDs, oxicam derivatives appeared to have the greatest association with SJS and TEN. The relative risks reported with other NSAIDs are much lower. The risk with cyclooxygenase-2-selective NSAIDs and meloxicam is less clear, since all were introduced after the completion of the epidemiologic studies. SJS or TEN from NSAIDs and cyclooxygenase-2-selective NSAIDs appears to affect the same patient population as other medications that cause SJS or TEN. The risk of SJS or TEN caused by NSAIDs is extremely low (less than 2 per 1 million users per week for oxicam derivatives, less than 1 per 1 million users per week for other NSAIDs, and 6 cases per 1 million person-years for celecoxib). Aspirin is not typically associated with SJS or TEN. Of ...Continue Reading

References

Oct 14, 1978·British Medical Journal·J A HunterR Mackie
May 1, 1991·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·J C ChanJ A Critchley
Aug 1, 1988·Journal of the American Academy of Dermatology·R E MassulloE Jacobsen
Apr 1, 1988·Journal of the American Academy of Dermatology·J S StottsH K Steinman
Jan 1, 1987·Zeitschrift für Rechtsmedizin. Journal of legal medicine·N IkedaT Suzuki
Sep 1, 1987·Archives of Dermatology·J C GuillaumeR Touraine
Jan 1, 1986·International Archives of Allergy and Applied Immunology·G RoupeM Suurküla
Jul 1, 1982·Archives of Internal Medicine·G D ParkM Goldberg
Feb 1, 1983·British Journal of Rheumatology·M O'SullivanM Molloy
Aug 1, 1981·Clinical Pharmacology and Therapeutics·C A NaranjoD J Greenblatt
Dec 14, 1995·The New England Journal of Medicine·J C RoujeauF Locati
Jan 1, 1995·Dermatology : International Journal for Clinical and Investigative Dermatology·G J TijhuisS J Smith
Mar 1, 1993·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·C M BaroneA Mitra
Mar 1, 1996·Postgraduate Medical Journal·J T Lear, J S English
Dec 29, 1998·Archives of Otolaryngology--head & Neck Surgery·J E BarreraE C Hartford
Mar 10, 1999·Journal of the American Academy of Dermatology·C A EganJ J Zone
Aug 10, 1999·Burns : Journal of the International Society for Burn Injuries·E C Smoot
Dec 3, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·J S YusinW B Klaustermeyer
Nov 21, 2001·Digestive Diseases and Sciences·M S Morelli, F X O'Brien
Sep 12, 2002·Pharmacotherapy·Peter BergerCarmela E Corallo
Nov 12, 2002·Southern Medical Journal·Bruce FriedmanEdward Law
Apr 12, 2003·Pharmacotherapy·Denise L Glasser, Susan H Burroughs
Aug 4, 2004·The Journal of Pediatrics·M TaghianE Jacquemin
Mar 9, 2005·Photodermatology, Photoimmunology & Photomedicine·A T Mansur, I A Aydingöz
May 7, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Erik LetkoC Stephen Foster
Sep 27, 2005·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Lois La GrenadeAllen Brinker
Jul 29, 2006·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Deborah LaytonSaad A W Shakir
Aug 9, 2006·Archives of Pediatrics & Adolescent Medicine·Jason S Reichenberg, Mark D P Davis

❮ Previous
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Citations

Oct 23, 2012·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Maria Spriggs, Chris Reeder
Nov 20, 2012·Nihon rinsho. Japanese journal of clinical medicine·Chikako Koshiji, Yutaka Imai
Jan 14, 2016·Current Allergy and Asthma Reports·Kevin A Cook, Andrew A White
Apr 14, 2015·Burns : Journal of the International Society for Burn Injuries·Hajirah SaeedJames Chodosh
Jan 7, 2016·Chemical Research in Toxicology·Richard A ThompsonDominic P Williams
Oct 26, 2010·Oral and Maxillofacial Surgery Clinics of North America·Richard P SzumitaNancy Just
Oct 18, 2016·Drug Safety - Case Reports·Sabyasachi PaikSantanu K Tripathi
Feb 26, 2016·CNS Drugs·Eman BahraniJoseph S Kass
Mar 13, 2012·Journal of Clinical Apheresis·Milan KoštálJaroslav Malý
Apr 16, 2015·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Keith K BurkhartDavid Jackson
Jun 10, 2014·Clinical Biochemistry·Bhushan M KapurJulie L V Shaw
Oct 8, 2016·Immunology and Allergy Clinics of North America·Kristen M Walters, Katharine M Woessner
Apr 30, 2015·The Journal of International Medical Research·Giovanni Cremonesi, Luca Cavalieri
Mar 10, 2015·Allergy, Asthma & Immunology Research·Marek L Kowalski, Joanna S Makowska
Jan 13, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Anthony R MawsonSridhar Karre
Dec 8, 2019·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·Zhuo Ran CaiAlexandre Mathieu
Dec 17, 2014·Pharmacogenetics and Genomics·Liudmila L MazaleuskayaTeri E Klein
Aug 5, 2014·Expert Review of Clinical Immunology·Ahmad A Mourad, Sami L Bahna
May 27, 2015·Journal of Clinical Pharmacy and Therapeutics·S SjövallH Kokki
Dec 1, 2015·Nature Biotechnology·Brian A KiddJoel T Dudley
Jun 27, 2020·Journal of Pharmacy Practice·Michael KhazakaAlexandre Mathieu
May 21, 2019·Current Opinion in Allergy and Clinical Immunology·Youngsoo LeeHae-Sim Park
May 24, 2016·The Journal of the American Osteopathic Association·Allison H ScotchAdriane I Budavari
Sep 18, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·S Walsh

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