PMID: 16508230Mar 2, 2006Paper

Severe alcoholic hepatitis with extremely high neutrophil count successfully treated by granulocytapheresis

Internal Medicine
Kentaro OkuboKendo Kiyosawa

Abstract

We report a severe alcoholic hepatitis (SAH) patient with an extremely high WBC count, high serum bilirubin and low prothrombin time (PT) successfully treated with granulocytapheresis. After neutrophil-elastase inhibitor failed to reduce WBC count, methylprednisolone pulse therapy was performed. However, WBC count continued to be elevated to 97,190/microl (neutrophils 97.0%) despite improvement of total bilirubin and PT. After 5 sessions of granulocytapheresis and ulinastatin administration, increased serum IL-6, IL-8, neutrophil-elastase and WBC count gradually decreased. We could conclude that granulocytapheresis and ulinastatin can be very effective in reducing cytokines and neutrophil-elastase, and in improving the general status of SAH patients.

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Citations

Feb 15, 2012·Journal of Gastroenterology and Hepatology·Yoshinori Horie
Sep 21, 2013·Digestive Diseases and Sciences·Kenya KamimuraYutaka Aoyagi
Oct 30, 2012·Clinics in Liver Disease·Umair Sohail, Sanjaya K Satapathy
Aug 16, 2011·Clinics and Research in Hepatology and Gastroenterology·Yoshinori HorieToshifumi Hibi
Dec 25, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Robert S O'SheaUNKNOWN Practice Parameters Committee of the American College of Gastroenterology
Nov 12, 2009·The American Journal of Gastroenterology·Robert S O'SheaArthur J McCullough
Dec 3, 2016·World Journal of Clinical Cases·Yukari WatanabeShuji Terai

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